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- Title
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.
- Authors
Lahortiga, Idoya; De Keersmaecker, Kim; Van Vlierberghe, Pieter; Graux, Carlos; Cauwelier, Barbara; Lambert, Frederic; Mentens, Nicole; Beverloo, H. Berna; Pieters, Rob; Speleman, Frank; Odero, Maria D.; Bauters, Marijke; Froyen, Guy; Marynen, Peter; Vandenberghe, Peter; Wlodarska, Iwona; Meijerink, Jules P. P.; Cools, Jan
- Abstract
We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
- Subjects
ONCOGENES; T cells; LYMPHOBLASTIC leukemia; T cell differentiation; LYMPHOBLASTIC leukemia treatment; THERAPEUTICS
- Publication
Nature Genetics, 2007, Vol 39, Issue 5, p593
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng2025