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- Title
Brain region-specific alterations of 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> receptors in serotonin transporter knockout mice.
- Authors
Li, Qian; Wichems, Christine H.; Ma, Li; Van de Kar, Louis D.; Garcia, Francisca; Murphy, Dennis L.
- Abstract
Abstract The aim of the present studies was to determine the effects of reduced or absent serotonin (5-HT) transporters (5-HTTs) on 5-HT2A and 5-HT2C receptors. The density of 5-HT2C receptors was significantly increased in the amygdala and choroid plexus of 5-HTT knockout mice. On the other hand, the density of 5-HT2A receptors was significantly increased in the hypothalamus and septum, but reduced in the striatum, of 5-HTT knockout mice. However, 5-HT2A mRNA was not changed in any brain region measured. 5-HT2C mRNA was significantly reduced in the choroid plexus and lateral habenula nucleus of these mice. The function of 5-HT2A receptors was evaluated by hormonal responses to (+/–)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). Oxytocin, but not adrenocorticotrophic hormone or corticosterone, responses to DOI were significantly greater in 5-HTT knockout mice. In addition, Gq and G11 proteins were not significantly changed in any brain region measured. The present results suggest that the constitutive alteration in the function of 5-HTTs changes the density of 5-HT2A and 5-HT2C receptors in a brain region-specific manner. These changes may not be mediated by alterations in their gene expression or in the level of Gq/11 proteins. The alterations in these receptors may be related to the altered behaviors of 5-HTT knockout mice.
- Subjects
SEROTONIN; HORMONE receptors
- Publication
Journal of Neurochemistry, 2003, Vol 84, Issue 6, p1256
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1046/j.1471-4159.2003.01607.x