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- Title
Self‐Assembly of Supramolecular DNA Amphiphiles through Host–Guest Interaction and Their Stimuli‐Responsiveness.
- Authors
Yuan, Wei; Ma, Jiahui; Zhao, Zhiyong; Liu, Simin
- Abstract
Smart DNA nanostructures have found potential application in material science and biomedicine. Most building blocks are DNA amphiphiles covalently synthesized from DNA and hydrophobic molecules. Here, the noncovalent approach based on the host–guest interaction between cucurbit[7]uril (CB[7]) and two hydrophobic guests with different topologies is utilized to modularly construct supramolecular DNA amphiphiles including DNA‐CB[7]/ferrocene derivative and DNA‐CB[7]/adamantine derivative. Both of the supramolecular DNA amphiphiles assemble into uniform spherical micelles, which can encapsulate hydrophobic Nile Red molecules and anchor gold nanoparticles through DNA hybridization. In addition, 1‐adamantanamine hydrochloride, a competitive guest with a strong binding constant with CB[7], induces the dissociation of DNA‐CB[7]/ferrocene derivative micelles. More importantly, the redox properties of ferrocene induce reversible morphology changes between the spherical micelles and the dissociated state. These stimuli‐responsive DNA supra‐amphiphilic micelles, as novel vehicles, expand the family of smart DNA nanostructures.
- Subjects
AMPHIPHILES; DNA; MATERIALS science; DNA nanotechnology; GOLD nanoparticles; BINDING constant
- Publication
Macromolecular Rapid Communications, 2020, Vol 41, Issue 9, p1
- ISSN
1022-1336
- Publication type
Article
- DOI
10.1002/marc.202000022