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- Title
Pediatric hemispheric high-grade glioma: targeting the future.
- Authors
Coleman, Christina; Stoller, Schuyler; Grotzer, Michael; Stucklin, Ana Guerreiro; Nazarian, Javad; Mueller, Sabine
- Abstract
Pediatric high-grade gliomas (pHGGs) are a group of tumors affecting approximately 0.85 children per 100,000 annually. The general outcome for these tumors is poor with 5-year survival rates of less than 20%. It is now recognized that these tumors represent a heterogeneous group of tumors rather than one entity. Large-scale genomic analyses have led to a greater understanding of the molecular drivers of different subtypes of these tumors and have also aided in the development of subtype-specific therapies. For example, for pHGG with NTRK fusions, promising new targeted therapies are actively being explored. Herein, we review the clinico-pathologic and molecular classification of these tumors, historical treatments, current management strategies, and therapies currently under investigation.
- Subjects
GLIOMAS; TUMOR classification; GLIOBLASTOMA multiforme
- Publication
Cancer & Metastasis Reviews, 2020, Vol 39, Issue 1, p245
- ISSN
0167-7659
- Publication type
Article
- DOI
10.1007/s10555-020-09850-5