We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Reduced speed of microvascular blood flow in hemodialysis patients versus healthy controls: a coherent hemodynamics spectroscopy study.
- Authors
Pierro, Michele L.; Kainerstorfer, Jana M.; Civiletto, Amanda; Weiner, Daniel E.; Sassaroli, Angelo; Hallacoglu, Bertan; Fantini, Sergio
- Abstract
We present a pilot clinical application of coherent hemodynamics spectroscopy (CHS), a technique to investigate cerebral hemodynamics at the microcirculatory level. CHS relies on frequency-resolved measurements of induced cerebral hemodynamic oscillations that are measured with near-infrared spectroscopy (NIRS) and analyzed with a hemodynamic model. We have used cyclic inflation (200 mmHg) and deflation of a pneumatic cuff placed around the subject's thigh at seven frequencies in the range of 0.03 to 0.17 Hz to generate CHS spectra and to obtain a set of physiological parameters that include the blood transit times in the cerebral micro-circulation, the cutoff frequency for cerebral autoregulation, and blood volume ratios across the three different compartments. We have investigated five hemodialysis patients, during the hemodialysis procedure, and six healthy subjects. We have found that the blood transit time in the cerebral microcirculation is significantly longer in hemodialysis patients with respect to healthy subjects. No significant differences were observed between the two groups in terms of autoregulation efficiency and blood volume ratios. The demonstration of the applicability of CHS in a clinical setting and its sensitivity to the highly important cerebral microcirculation may open up new opportunities for NIRS applications in research and in medical diagnostics and monitoring.
- Subjects
NEAR infrared spectroscopy; HEMODYNAMICS; HEMODIALYSIS; PATHOLOGICAL physiology; CEREBRAL circulation
- Publication
Journal of Biomedical Optics, 2014, Vol 19, Issue 2, p1
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.JBO.19.2.026005