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- Title
Evaluation of the trabecular bone score in 35 children and adults with X-linked hypophosphatemic rickets.
- Authors
de Paula Colares Neto, Guido; Pereira, Rosa Maria Rodrigues; Alvarenga, Jackeline Couto; Takayama, Liliam; de Assis Funari, Mariana Ferreira; Martin, Regina Matsunaga
- Abstract
Introduction: The aim of this study is to evaluate and compare the trabecular bone scores (TBSs) of 11 children and 24 adults with X-linked hypophosphatemic rickets (XLH) and non-XLH subjects from a tertiary center. Materials and methods: The areal bone mineral density at the lumbar spine (LS-aBMD) and LS-aBMD Z score were analyzed by dual-energy X-ray absorptiometry. The bone mineral apparent density (BMAD) and LS-aBMD Z score adjusted for height Z score (LS-aBMD–HAZ) were calculated. The TBS was determined using TBS iNsight software based on DXA images from the Hologic QDR 4500 device. Results: The XLH patients exhibited a higher mean LS-aBMD Z score, BMAD, and TBS than the non-XLH subjects (p < 0.01). LS-aBMD–HAZ and BMAD were greater in the XLH children than those in their corresponding non-XLH subjects (p < 0.01 and p = 0.02), and the XLH children trended toward a greater TBS (p = 0.06). The XLH adults had a higher LS-aBMD Z score, BMAD, and TBS than the non-XLH subjects (p < 0.01). When stratified by metabolic status according to the serum values of bone formation markers, compensated adult patients had a higher LS-aBMD Z score, BMAD, and TBS than non-XLH subjects (p < 0.01). Noncompensated patients had higher LS-aBMD Z scores and BMAD results than non-XLH subjects. However, TBS values did not differ statistically significantly between those groups (p = 0.45). Conclusion: The higher LS-aBMD Z score, BMAD, and TBS result in the XLH patients compared to non-XLH subjects indicates an increased amount of trabecular bone within the lumbar spine, regardless of extraskeletal calcifications.
- Subjects
CANCELLOUS bone; LUMBAR vertebrae; BONE density; RICKETS; DUAL-energy X-ray absorptiometry; BONE growth
- Publication
Journal of Bone & Mineral Metabolism, 2023, Vol 41, Issue 5, p666
- ISSN
0914-8779
- Publication type
Article
- DOI
10.1007/s00774-023-01442-x