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- Title
Cell type-specific enhancer element associated with a mouse MHC gene, E<sub>β</sub>.
- Authors
Gillies, Stephen D.; Folsom, Virginia; Tonegawa, Susumu
- Abstract
Class II molecules of the major histocompatibility complex (MHC) are heterodimeric glycoproteins expressed on the surface of antigen-presenting B lymphocytes and macrophages1. The genes encoding the α- and β-chains of the class II heterodimers, AαAβ and EαEβ, have recently been characterized at the molecular level2-5, and certain cloned genes were shown to be functionally expressed after introduction into cells by DNA-mediated gene transfer6,7. One study7 found that a transfected Ebβ gene was expressed in a macrophage cell only after treatment of cells with γ-interferon. DNA sequences associated with transfected Class II MHC genes may therefore have a regulatory role in their cell type-specific expression. We report here the identification of a cell type-specific transcriptional enhancer element associated with the mouse Edβ gene.
- Publication
Nature, 1984, Vol 310, Issue 5978, p594
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/310594a0