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- Title
Somatic generation of antibody diversity.
- Authors
Tonegawa, Susumu
- Abstract
In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the formation of a complete gene. In addition, mutations are somatically introduced at a high rate into the amino-terminal region. Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism.
- Publication
Nature, 1983, Vol 302, Issue 5909, p575
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/302575a0