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- Title
Two New Coumarins from the Roots and Stems of Nicotiana tabacum and their Bioactivity.
- Authors
Zhu, Li-Jun; Luo, Dian; Lv, Na; Li, Yin-ke; Mi, Qi-Li; Wang, Jin; Kong, Wei-Song; Gao, Qian; Li, Gan-Peng; Yang, Guang-Yu; Hu, Qiu-Fen; Guan, Ying; Ye, Yan-Qing
- Abstract
Two new coumarins, 6-hydroxymethyl-3-prenyl-7-methoxycoumarin (1) and 6-hydroxyethyl-3-prenyl-7- methoxycoumarin (2), together with three known coumarins (3–5), were isolated from the roots and stems of Yunyan-300, a variety of Nicotiana tabacum L. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-methicillinresistant Staphylococcus aureus (anti-MRSA) activity and their antioxidant activity. The results revealed that compounds 1 and 2 showed good anti-MRSA inhibitions with IZD of 12.2 ± 1.8 and 11.8 ± 1.5 mm, respectively, and antioxidant activity with an IC50 value of 4.65 and 4.85 μg/mL, respectively.
- Subjects
TOBACCO; STAPHYLOCOCCUS aureus
- Publication
Chemistry of Natural Compounds, 2020, Vol 56, Issue 5, p806
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-020-03157-1