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- Title
Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis.
- Authors
Verleye, Arno; Wijtvliet, Veerle; Abrams, Steven; Hellemans, Rachel; Bougrea, Rania; Massart, Annick; Pipeleers, Lissa; Wissing, Karl Martin; Ariën, Kevin K; Winter, Benedicte Y De; Damme, Pierre Van; Abramowicz, Daniel; Ledeganck, Kristien J
- Abstract
Background In the general population, the seroconversion rate after primary vaccination with two doses of an anti-severe acute respiratory syndrome coronavirus 2 messenger RNA (mRNA) vaccine reaches nearly 100%, with significantly higher antibody titers after mRNA-1273 vaccination compared to BNT162b2 vaccination. Here we performed a systematic review and meta-analysis to compare the antibody response after two-dose mRNA-1273 versus BNT162b2 vaccination in solid organ transplant (SOT) recipients. Methods A systematic literature review was performed using PubMed, Web of Science and the Cochrane Library and original research papers were included for a meta-analysis to calculate vaccine-specific seroconversion rates for each of the mRNA vaccines. Next, the pooled relative seroconversion rate was estimated. Results Eight studies that described the development of antibodies against receptor-binding domain (RBD) and/or spike protein were eligible for meta-analysis. Two of these studies also reported antibody titers. The meta-analysis revealed lower seroconversion rates in SOT recipients vaccinated with two doses of BNT162b2 {44.3% [95% confidence interval (CI) 34.1–54.7]} as compared with patients vaccinated with two doses of mRNA-1273 [58.4% (95% CI 47.2–69.2)]. The relative seroconversion rate was 0.795 (95% CI 0.732–0.864). Conclusions This systematic review and meta-analysis indicates that in SOT recipients, higher seroconversion rates were observed after vaccination with mRNA-1273 compared with BNT162b2.
- Subjects
TRANSPLANTATION of organs, tissues, etc.; COVID-19 vaccines; SEROCONVERSION; VACCINATION; ANTIBODY titer
- Publication
Nephrology Dialysis Transplantation, 2022, Vol 37, Issue 8, p1566
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfac174