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- Title
Solute solver 'what if' module for modeling urea kinetics.
- Authors
Daugirdas, John T.
- Abstract
Background. The publicly available Solute Solver module allows calculation of a variety of two-pool urea kinetic measures of dialysis adequacy using pre- and postdialysis plasma urea and estimated dialyzer clearance or estimated urea distribution volumes as inputs. However, the existing program does not have a 'what if' module, which would estimate the plasma urea values as well as commonly used measures of hemodialysis adequacy for a patient with a given urea distribution volume and urea nitrogen generation rate dialyzed according to a particular dialysis schedule. Methods. Conventional variable extracellular volume 2-pool urea kinetic equations were used. Results. A javascript-HTML Web form was created that can be used on any personal computer equipped with internet browsing software, to compute commonly used Kt/V-based measures of hemodialysis adequacy for patients with differing amounts of residual kidney function and following a variety of treatment schedules. Conclusions. The completedWeb form calculator may be particularly useful in computing equivalent continuous clearances for incremental hemodialysis strategies.
- Subjects
HEMODIALYSIS; BLOOD urea nitrogen; KIDNEY function tests; MEDICAL appointments; BLOOD plasma
- Publication
Nephrology Dialysis Transplantation, 2016, Vol 31, Issue 11, p1934
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfw311