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- Title
F-056 PROPOSAL FOR NEW CLINICAL T FACTOR OF THE NEXT EDITION OF TNM CLASSIFICATION IN NON-SMALL-CELL LUNG CANCER USING THE CONSOLIDATION DIAMETER OR CONSOLIDATION TO TUMOUR RATIO ON THIN-SECTION COMPUTED TOMOGRAPHY.
- Authors
Shunki, Hirayama; Aokage, K.; Nao, A.; Hishida, T.; Yoshida, J.
- Abstract
Objectives: The opportunity to encounter the lung tumour with ground glass component has been increasing with marked improvement of computed tomography (CT) technology in our daily practice. The consolidation diameter or consolidation to tumour (C/T) ratio on thin-section CT (TSCT) have been widely recognized as better prognostic indicators than tumour size in non-small-cell lung cancer (NSCLC), but are not included in the seventh TNM classification. The aim of this study was to clarify which parameter reflects patients' prognosis more exactly and is more suitable as a new clinical T-descriptor.Methods: We measured the consolidation diameter and C/T ratio in the lung field on TSCT for the 1074 resected NSCLC patients with cT1-3N0M0 between January 2002 and December 2008. We compared and analyzed the overall survival curves categorized at 10 mm interval in consolidation diameter and those in patients with ground glass opacity (GGO)-predominant (C/T ratio 0.5 or less) or consolidation-predominant (C/T ratio more than 0.5).Results: The median follow-up period was 5.5 year. Overall survival curves categorized in consolidation diameter were clearly separated. The 5-year survival rate in patients with GGO-predominant tumours of less than 20 mm, 21 to 30 mm and 31 to 50 mm were 100%, 96% and 100%, respectively. The 5-year survival rate of less than 30 mm, 31 to 50 mm, 51 to 70 mm and 71 mm- in patients with consolidation-predominant tumours were 81%, 67%, 51% and 36%, respectively.Conclusions: The patients with GGO-predominant tumours revealed extremely good prognosis regardless of the tumour size. Survival curves categorized by consolidation diameter and tumour size were clearly separated in appearance. But a good prognostic population as the patients with GGO-predominant tumours were not extracted as an independent entity. We offer to include C/T ratio in a new clinical T description of NSCLC.Disclosure: No significant relationships.
- Publication
Interactive Cardiovascular & Thoracic Surgery, 2014, Vol 18, Issue suppl_1, pS14
- ISSN
1569-9293
- Publication type
Article
- DOI
10.1093/icvts/ivu167.56