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- Title
Adeno-associated Virus Vectors Serotype 2 Induce Prolonged Proliferation of Capsid-Specific CD8<sup>+</sup> T Cells in Mice.
- Authors
Hua Li; Tuyishime, Steven; Te-Lang Wu; Giles-Davis, Wynetta; Dongming Zhou; Weidong Xiao; High, Katherine A.; Ertl, Hildegund C. J.
- Abstract
Using adoptive transfer models we determined that an adeno-associated viral vector of serotype 2 (AAV2) induces in mice proliferation of CD8+ T cells that recognize an epitope within the viral capsid. Proliferation to an endogenous epitope within viral protein (VP)3 could be observed for at least 3 weeks while a foreign epitope placed at multiple copies within VP2 elicited CD8+ T cell expansion for at least 10 weeks. These data show that capsid antigens of AAV2 degrade slowly over a period of weeks and during this period provide targets to CD8+ T cells.
- Subjects
GENE therapy; CELLULAR therapy; ADENOCARCINOMA; SEROTYPES; LABORATORY mice; MIRIDAE; ANTIGENS
- Publication
Molecular Therapy, 2011, Vol 19, Issue 3, p536
- ISSN
1525-0016
- Publication type
Article
- DOI
10.1038/mt.2010.267