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- Title
Genetic and Pharmacological Inhibition of GCN2 Ameliorates Hyperglycemia and Insulin Resistance in Type 2 Diabetic Mice.
- Authors
Yuan, Juntao; Li, Fang; Shen, Xiyue; Gao, Junling; Yu, Zhuoran; Luo, Kai; Cui, Bingqing; Lu, Zhongbing
- Abstract
Since hepatic lipid accumulation plays an important role in developing whole-body insulin resistance [[32]], the GCN2 inhibition-mediated alleviation of hepatic steatosis may also be responsible for the increased insulin sensitivity in T2D mice. Keywords: type 2 diabetes; GCN2; hyperglycemia; insulin resistance; hepatic steatosis; oxidative stress EN type 2 diabetes GCN2 hyperglycemia insulin resistance hepatic steatosis oxidative stress N.PAG N.PAG 13 08/29/22 20220801 NES 220801 1. Inhibition of GCN2 Improves Insulin Sensitivity and Alleviates Hepatic Steatosis and Oxi... To investigate whether inhibition of GCN2 could be a potential therapeutic approach for T2DM, we used the GCN2-specific inhibitor GCN2iB to treat two T2D mouse models.
- Subjects
HYPERGLYCEMIA; INSULIN resistance; MICE
- Publication
Antioxidants, 2022, Vol 11, Issue 8, pN.PAG
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11081584