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- Title
Teratogenic Effects of Di(2-ethylhexyl) phthalate (DEHP) on Zebrafish Embryos.
- Authors
Dahiwal, Arundhati; D'Souza, Roshan C.
- Abstract
Developmental toxicity studies help to understand the impact of a pollutant on this crucial phase of the living organisms which can affect their population dynamics. Zebrafish has become an ideal model for studying environmental and embryo toxicity. The present study was carried out using zebrafish embryos for assessing the environmental toxicity of Di(2-ethylhexyl) phthalate (DEHP) which is universally considered to be an omnipresent environmental contaminant as it is the most widely used plasticizer. The embryos were exposed to DEHP for a range of five concentrations of 0.2, 20, 80, 140 and 200 μg/L for the duration of 96 hours. The treatment resulted in increased mortality and decreased hatch rate, hatchability and heartrate. It also induced teratogenic endpoints like yolk sac edema, pericardial edema and spinal deformity in the embryos which increased in dose and time dependent manner.
- Subjects
ZEBRA danio embryos; EMBRYOS; YOLK sac; BRACHYDANIO; SPINE abnormalities; POPULATION dynamics; PHTHALATE esters
- Publication
Journal of Advanced Zoology, 2024, Vol 45, Issue 4, p96
- ISSN
0253-7214
- Publication type
Article