We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Disparities in parental distress in a multicenter clinical trial for pediatric acute lymphoblastic leukemia.
- Authors
Umaretiya, Puja J; Koch, Victoria B; Flamand, Yael; Aziz-Bose, Rahela; Ilcisin, Lenka; Valenzuela, Ariana; Cole, Peter D; Gennarini, Lisa M; Kahn, Justine M; Kelly, Kara M; Tran, Thai Hoa; Michon, Bruno; Welch, Jennifer J G; Wolfe, Joanne; Silverman, Lewis B; Bona, Kira
- Abstract
Background Parent psychological distress during childhood cancer treatment has short- and long-term implications for parent, child, and family well-being. Identifying targetable predictors of parental distress is essential to inform interventions. We investigated the association between household material hardship (HMH), a modifiable poverty-exposure defined as housing, food, or utility insecurity, and severe psychological distress among parents of children aged 1-17 years with acute lymphoblastic leukemia (ALL) enrolled on the multicenter Dana-Farber ALL Consortium Trial 16-001. Methods This was a secondary analysis of parent-reported data. Parents completed an HMH survey within 32 days of clinical trial enrollment (T0) and again at 6 months into therapy (T1). The primary exposure was HMH at T0 and primary outcome was severe parental distress at T0 and T1, defined as a score greater than or equal to 13 on the Kessler-6 Psychological Distress Scale. Multivariable models were adjusted for ALL risk group and single parent status. Results Among 375 evaluable parents, one-third (32%; n = 120/375) reported HMH at T0. In multivariable analyses, T0 HMH was associated with over twice the odds of severe psychological distress at T0 and T1 HMH was associated with over 5 times the odds of severe distress at T1. Conclusions Despite uniform clinical trial treatment of their children at well-resourced pediatric centers, HMH-exposed parents—compared with unexposed parents—experienced statistically significantly increased odds of severe psychological distress at the time of their child's leukemia diagnosis, which worsened 6 months into therapy. These data identify a high-risk parental population who may benefit from early psychosocial and HMH-targeted interventions to mitigate disparities in well-being.
- Subjects
LYMPHOBLASTIC leukemia; ACUTE leukemia; CLINICAL trials; SINGLE parents; PSYCHOLOGICAL distress
- Publication
JNCI: Journal of the National Cancer Institute, 2023, Vol 115, Issue 10, p1179
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djad099