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- Title
Association between diarrhea and quality of life in HIV-infected patients receiving highly active antiretroviral therapy.
- Authors
Tramarin, Andrea; Parise, Nicoletta; Campostrini, Stefano; Yin, Donald D.; Postma, Maarten J.; Lyu, Ramon; Grisetti, Roberta; Capetti, Amedeo; Cattelan, Anna Maria; Di Toro, Maria Teresa; Mastroianni, Antonio; Pignattari, Elena; Mondardini, Valeria; Calleri, Guido; Raise, Enzo; Starace, Fabrizo; Starace, Fabrizio; Palladio Study Group
- Abstract
Diarrhea is a common symptom that many HIV patients experience either as a consequence of HIV infection or of highly active antiretroviral therapy (HAART). A multicenter, prospective observational study was conducted in 11 AIDS clinics in Italy to determine the effect of diarrhea on health-related quality of life among patients receiving HAART. The study enrolled 100 consecutive HIV positive patients who had diarrhea while on HAART. For each enrolled patient a control patient with matching disease stage who did not have diarrhea was identified using existing data from another prospective observational study conducted in 34 AIDS clinics (including the 11 in current study). Quality of life was measured by MOS-HIV Health Survey (MOS-HIV). Paired t-test and multiple regression analysis were used to compare the quality of life among patients with and without diarrhea. Mean patient age was 40 +/- 7 years; 69% were male. Mean CD4 cell count was 342 +/- 239 cells/mm3; 59% had AIDS. Of the cases, 49 patients had severe diarrhea (> 5 bowel movements or > 3 watery per day) and 46 patients had moderate diarrhea (3-5 bowel movements). Compared to matched control patients, cases experiencing diarrhea while on HAART had significantly lower MOS-HIV scores in all domains. The significant adverse effect of diarrhea on quality of life should be considered when choosing the appropriate antiretroviral drugs regimen.
- Subjects
ITALY; QUALITY of life; HIV-positive persons; HEALTH; DIARRHEA; SYMPTOMS; ANTIRETROVIRAL agents; THERAPEUTICS; HIV infections &; psychology; MENTAL health; HIV infection complications; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; QUESTIONNAIRES; REGRESSION analysis; RESEARCH; SICKNESS Impact Profile; EVALUATION research; HIGHLY active antiretroviral therapy; CASE-control method; ANTI-HIV agents; PSYCHOLOGY
- Publication
Quality of Life Research, 2004, Vol 13, Issue 1, p243
- ISSN
0962-9343
- Publication type
journal article
- DOI
10.1023/B:QURE.0000015282.24774.36