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- Title
Niclosamide enhances the antitumor effects of radiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signaling pathway in human lung cancer cells.
- Authors
MEI XIANG; ZIHONG CHEN; DONGHONG YANG; HAIWEN LI; YUFANG ZUO; JINGJING LI; WENDIAN ZHANG; HECHAO ZHOU; DANXIAN JIANG; ZUMIN XU; ZHONGHUA YU
- Abstract
Lung cancer is one of the leading causes of cancer-associated mortality, worldwide. The overall survival rate remains low, but progress has been made in improving the diagnosis and treatment of lung cancer over the past decades. Niclosamide, a salicylanilide derivative used for the treatment of tapeworm infections, is safe, well tolerated, inexpensive and readily available. Previous studies have identified niclosamide as a potential anticancer agent. The present study demonstrated that niclosamide enhanced the effect of irradiation by inhibiting the hypoxia-inducible factor-1a/vascular endothelial growth factor signaling pathway. These findings suggest that niclosamide may be a promising candidate for clinical evaluation as part of a combined regimen for the treatment of non-small cell lung cancer.
- Subjects
ANTINEOPLASTIC agents; HYPOXIA-inducible factor 1; VASCULAR endothelial growth factors; CELLULAR signal transduction; CANCER treatment; NON-small-cell lung carcinoma; CANCER-related mortality
- Publication
Oncology Letters, 2017, Vol 14, Issue 2, p1933
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2017.6372