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- Title
Clinical Features Associated With Individuals at Higher Risk of Melanoma: A Population-Based Study.
- Authors
Watts, Caroline G.; Madronio, Christine; Morton, Rachael L.; Goumas, Chris; Armstrong, Bruce K.; Curtin, Austin; Menzies, Scott W.; Mann, Graham J.; Thompson, John F.; Cust, Anne E.
- Abstract
<bold>Importance: </bold>The identification of a subgroup at higher risk of melanoma may assist in early diagnosis.<bold>Objective: </bold>To characterize melanoma patients and the clinical features associated with their melanomas according to patient risk factors: many nevi, history of previous melanoma, and family history of melanoma, to assist with improving the identification and treatment of a higher-risk subgroup.<bold>Design, Setting, and Participants: </bold>The Melanoma Patterns of Care study was a population-based observational study of physicians' reported treatment of 2727 patients diagnosed with an in situ or invasive primary melanoma over a 12-month period from October 2006 to 2007 conducted in New South Wales. Our analysis of these data took place from 2015 to 2016.<bold>Main Outcomes and Measures: </bold>Age at diagnosis and body site of melanoma.<bold>Results: </bold>Of the 2727 patients with melanoma included, 1052 (39%) were defined as higher risk owing to a family history of melanoma, multiple primary melanomas, or many nevi. Compared with patients with melanoma who were at lower risk (ie, without any of these risk factors), the higher-risk group had a younger mean age at diagnosis (62 vs 65 years, P < .001), but this differed by risk factor (56 years for patients with a family history, 59 years for those with many nevi, and 69 years for those with a previous melanoma). These age differences were consistent across all body sites. Among higher-risk patients, those with many nevi were more likely to have melanoma on the trunk (41% vs 29%, P < .001), those with a family history of melanoma were more likely to have melanomas on the limbs (57% vs 42%, P < .001), and those with a personal history were more likely to have melanoma on the head and neck (21% vs 15%, P = .003).<bold>Conclusions and Relevance: </bold>These findings suggest that a person's risk factor status could be used to tailor surveillance programs and education about skin self-examination.
- Subjects
NEW South Wales; MELANOMA diagnosis; AGE factors in disease; ANTHROPOMETRY; EXTREMITIES (Anatomy); HEAD tumors; MELANOMA; NEVUS; MULTIPLE tumors; NECK tumors; SKIN tumors; TORSO; DIAGNOSIS
- Publication
JAMA Dermatology, 2017, Vol 153, Issue 1, p23
- ISSN
2168-6068
- Publication type
journal article
- DOI
10.1001/jamadermatol.2016.3327