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- Title
Over‐shedding of donor‐derived cell‐free DNA at immune‐related regions into plasma of lung transplant recipient.
- Authors
Luo, Jiaqi; Liu, Liping; Chen, Lingxi; Xu, Xin; Wang, Yanfei; Wei, Bing; Ju, Chunrong; Wang, Xuedong; Huang, Liyan; Zeng, Wenchuang; Miao, Xinyao; Sang, Ling; Huang, Danxia; Pan, Guangze; Peng, Guilin; Chen, Zhuxing; Zhao, Zicheng; Yang, Chao; Cui, Weixue; Jiang, Wenxi
- Abstract
The discovery of the positive correlation between the fraction of donor-derived cell-free DNA (cfDNA) in the recipient's plasma (herein denoted as donor DNA fraction) and the risk of organ transplant rejection has empowered the development of non-invasive methods for the prediction and prevention of organ transplant failure.1,2 However, as previous studies mainly focused on a global estimation of donor DNA fraction and usually have been conducted months post-transplant, some important questions remained unanswered. Over-shedding of donor-derived cell-free DNA at immune-related regions into plasma of lung transplant recipient Global donor DNA fraction of the three patients at days 1, 4, 7, 10, 13 (post-transplant) were predicted using the genome-wide SNP-based method. Blood samples were collected at day 0 (pre-transplant), and days 1,4,7,10,13 (post-transplant) from recipients of lung transplantation (LTx).
- Subjects
CELL-free DNA; LUNG transplantation; LUNGS; LYMPHOCYTE count; BASILIXIMAB
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 1, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.622