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- Title
Preparation and evaluation of ultrasound‐mediated dual‐targeted theragnostic systems utilising phase‐changeable polymeric nanodroplets on the integrin α<sub>ν</sub>β<sub>3</sub> overexpressed breast cancer.
- Authors
Li, Na; Duan, Shaobo; Wang, Yiwei; Zhang, Linlin; Chen, Yongqing; Zhang, Juan; Liu, Ruiqing; Li, Yaqiong; Liu, Luwen; Ren, Shanshan; Zhang, Ye; Guo, Yuqi; Ji, Zhenyu; Zhang, Lianzhong
- Abstract
Under US irradiation in situ, they can undergo a phase shift, produce stable and inertial cavitation, induce useful US bioeffects, and provide enhanced sonography and improved therapeutic effects5,6 that are ideal for targeted theragnostic systems. GLO:F2H7/01oct21:ctm2607-fig-0003.jpg PHOTO (COLOR): 3 (A) Dual-targeted theragnostic ultrasound contrast agent (DTTUCA) nanodroplets produced ultrasound (US)-enhanced images under CEUS and B model. (D) US-enhanced images of the MCF-7 cells de-bubbles medium, MCF-7 cells were co-incubated with DTTUCA nanodroplets for 40 min in an ice bath, then DTTUCA were removed, triple washed and replaced by de-bubbles medium, and observed under CEUS and B model. Breast cancer (BC) with overexpressed integrin SB sb SB 3 sb often indicates a high rate of metastasis and recurrence.1 Therefore, targeted theragnostic systems are urgently required.2,3 Cyclo(Arg-Gly-Asp-d-Tyr-Lys) peptide (cRGD) ligand-modified polymeric perfluorocarbon (PFC)-based nanodroplet ultrasound contrast agent (UCA)4 can extravasate in, selectively adhere to, and accumulate in BC tissues due to their nanoscale size, ultrasound (US)-mediated passive targeting and cRGD-mediated active targeting properties.
- Subjects
MICROBUBBLE diagnosis; BREAST cancer; DIAGNOSTIC ultrasonic imaging; INTEGRINS; ULTRASOUND contrast media
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 10, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.607