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- Title
The leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodies.
- Authors
Falcão, Michelle Miranda Lopes; Passos-Soares, Johelle Santana; Machado, Paulo Roberto Lima; Gomes-Filho, Isaac Suzart; de Carvalho, Lucas Pedreira; de Campos, Elisangela Jesus; Calheira, Mariana Costa; de Miranda, Patrícia Mares; Santos, Rebeca Pereira Bulhosa; Rocha Filho, José Tadeu Raynal; de Farias, Antonio Pedro Froes; Peixoto, Taiana; Nascimento, Roberto Meyer; Seymour, Gregory John; Trindade, Soraya Castro
- Abstract
The aim of the study was to evaluate the association between salivary anti-Porphyromonas gingivalis IgA antibodies and the leprosy reaction. The levels of salivary anti - P. gingivalis IgA antibodies, together with salivary flow and pH were measured in individuals diagnosed with leprosy and associated with the development of the leprosy reaction. Saliva was collected from 202 individuals diagnosed with leprosy at a reference leprosy treatment center, 106 cases with the leprosy reaction and 96 controls without the leprosy reaction. Anti - P. gingivalis IgA was evaluated by indirect immunoenzyme assay. Non-conditional logistic regression analysis was employed to estimate the association between antibody levels and the leprosy reaction. There was a positive statistically significant association between the levels of anti - P. gingivalis IgA and the presence of the leprosy reaction, controlling for confounders: age, sex, level of education and alcoholic beverage consumption: ORajusted: 2.55; IC 95%: 1.34–4.87. Individuals with leprosy who had high levels of salivary anti - P. gingivalis IgA had approximately twice as many chances of developing the leprosy reaction. The findings suggest a possible relationship between salivary anti - P. gingivalis IgA antibodies and the leprosy reaction. Key Points: Oral manifestations may predispose to the leprosy reaction. Salivary anti - P. gingivalis IgA antibodies are associated with leprosy reaction. Marker for leprosy reaction in individuals with periodontitis.
- Subjects
HANSEN'S disease; ALCOHOL drinking; IMMUNOGLOBULIN A; IMMUNOGLOBULINS; SALIVA; HEALTH facilities; LOGISTIC regression analysis
- Publication
AMB Express, 2023, Vol 13, Issue 1, p1
- ISSN
2191-0855
- Publication type
Article
- DOI
10.1186/s13568-023-01576-1