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- Title
Association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status: evidence from a cluster randomized controlled trial.
- Authors
Li, Shanshan; Mi, Baibing; Qu, Pengfei; Liu, Danmeng; Lei, Fangliang; Wang, Duolao; Zeng, Lingxia; Kang, Yijun; Shen, Yuan; Pei, Leilei; Zhu, Zhonghai; Yan, Hong; Liu, Xin; Dang, Shaonong
- Abstract
Purpose: Evidence about the effect of maternal vitamin B12 supplementation on offspring's vitamin B12 status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status. Methods: In an ongoing cluster randomized controlled trial conducted in three rural counties in northwest China, pregnant women < 20 weeks of gestation were randomized to three treatment groups: blank control, iron supplements, or vitamin B complex supplements. All women were administered folic acid supplements during the periconceptional period. In a sub-study, we collected cord blood samples of 331 participants from the control or vitamin B complex groups in the Xunyi county from January 2017 to December 2017. Plasma concentrations of folate, vitamin B12, and homocysteine were measured. Linear mixed models with a random intercept for cluster were used to compare biochemical indexes between groups after controlling for covariates. Results: Compared with newborns whose mothers were in the control group, newborns of the vitamin B complex-supplemented women had significantly higher cord plasma vitamin B12 (P = 0.001) and lower homocysteine concentrations (P = 0.043). The association of antenatal vitamin B complex supplementation with cord blood vitamin B12 concentrations appeared to be more pronounced among newborns with high folate status than those with low folate status (Pinteraction = 0.060). Conclusions: Maternal vitamin B complex supplementation during pregnancy was associated with better neonatal vitamin B12 status in rural northwest China.
- Subjects
CHINA; EXPERIMENTAL design; HOMOCYSTEINE; VITAMIN B12; PREGNANT women; VITAMIN B complex; DIETARY supplements; RANDOMIZED controlled trials; CORD blood; PRENATAL care; STATISTICAL sampling; FOLIC acid; PREGNANCY
- Publication
European Journal of Nutrition, 2021, Vol 60, Issue 2, p1031
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-020-02309-x