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- Title
Low-Molecular-Weight Fish Collagen Peptide (Valine-Glycine-Proline-Hydroxyproline-Glycine-Proline-Alanine-Glycine) Prevents Osteoarthritis Symptoms in Chondrocytes and Monoiodoacetate-Injected Rats.
- Authors
Cho, Wonhee; Park, Jeongjin; Kim, Jinhee; Lee, Minhee; Park, So Jung; Kim, Kyung Seok; Jun, Woojin; Kim, Ok-Kyung; Lee, Jeongmin
- Abstract
The objective of this study was to investigate the effect of low-molecular-weight fish collagen (valine-glycine-proline-hydroxyproline-glycine-proline-alanine-glycine; LMWCP) on H2O2- or LPS-treated primary chondrocytes and monoiodoacetate (MIA)-induced osteoarthritis rat models. Our findings indicated that LMWCP treatment exhibited protective effects by preventing chondrocyte death and reducing matrix degradation in both H2O2-treated primary chondrocytes and cartilage tissue from MIA-induced osteoarthritis rats. This was achieved by increasing the levels of aggrecan, collagen type I, collagen type II, TIMP-1, and TIMP-3, while simultaneously decreasing catabolic factors such as phosphorylation of Smad, MMP-3, and MMP-13. Additionally, LMWCP treatment effectively suppressed the activation of inflammation and apoptosis pathways in both LPS-treated primary chondrocytes and cartilage tissue from MIA-induced osteoarthritis rats. These results suggest that LMWCP supplementation ameliorates the progression of osteoarthritis through its direct impact on inflammation and apoptosis in chondrocytes.
- Subjects
PEPTIDES; CARTILAGE cells; COLLAGEN; OSTEOARTHRITIS; SYMPTOMS; RATS; ALANINE
- Publication
Marine Drugs, 2023, Vol 21, Issue 12, p608
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md21120608