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Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02075-4
By:
- Qiu, Runxiang;
- Wu, Jun;
- Gudenas, Brian;
- Northcott, Paul A.;
- Wechsler-Reya, Robert J.;
- Lu, Qiang
Publication type:
Article
Conventional Therapies Deplete Brain-Infiltrating Adaptive Immune Cells in a Mouse Model of Group 3 Medulloblastoma Implicating Myeloid Cells as Favorable Immunotherapy Targets.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.837013
By:
- Abbas, Zahra;
- George, Courtney;
- Ancliffe, Mathew;
- Howlett, Meegan;
- Jones, Anya C.;
- Kuchibhotla, Mani;
- Wechsler-Reya, Robert J.;
- Gottardo, Nicholas G.;
- Endersby, Raelene
Publication type:
Article
Molecular mechanisms and therapeutic targets in pediatric brain tumors.
Published in:
Science Signaling, 2017, v. 10, n. 470, p. 1, doi. 10.1126/scisignal.aaf7593
By:
- Kun-Wei Liu;
- Pajtler, Kristian W.;
- Worst, Barbara C.;
- Pfister, Stefan M.;
- Wechsler-Reya, Robert J.
Publication type:
Article
Developmental basis of SHH medulloblastoma heterogeneity.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-023-44300-0
By:
- Gold, Maxwell P.;
- Ong, Winnie;
- Masteller, Andrew M.;
- Ghasemi, David R.;
- Galindo, Julie Anne;
- Park, Noel R.;
- Huynh, Nhan C.;
- Donde, Aneesh;
- Pister, Veronika;
- Saurez, Raul A.;
- Vladoiu, Maria C.;
- Hwang, Grace H.;
- Eisemann, Tanja;
- Donovan, Laura K.;
- Walker, Adam D.;
- Benetatos, Joseph;
- Dufour, Christelle;
- Garzia, Livia;
- Segal, Rosalind A.;
- Wechsler-Reya, Robert J.
Publication type:
Article
Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development.
Published in:
PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0114433
By:
- Miller, Tyler E.;
- Wang, Jun;
- Sukhdeo, Kumar;
- Horbinski, Craig;
- Tesar, Paul J.;
- Wechsler-Reya, Robert J.;
- Rich, Jeremy N.
Publication type:
Article
Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08269-5
By:
- Lee, Catherine;
- Rudneva, Vasilisa A.;
- Erkek, Serap;
- Zapatka, Marc;
- Chau, Lianne Q.;
- Tacheva-Grigorova, Silvia K.;
- Garancher, Alexandra;
- Rusert, Jessica M.;
- Aksoy, Ozlem;
- Lea, Robin;
- Mohammad, Helai P.;
- Wang, Jianxun;
- Weiss, William A.;
- Grimes, H. Leighton;
- Pfister, Stefan M.;
- Northcott, Paul A.;
- Wechsler-Reya, Robert J.
Publication type:
Article
Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07182-1
By:
- Kahn, Suzana A.;
- Wang, Xin;
- Nitta, Ryan T.;
- Gholamin, Sharareh;
- Theruvath, Johanna;
- Hutter, Gregor;
- Azad, Tej D.;
- Wadi, Lina;
- Bolin, Sara;
- Ramaswamy, Vijay;
- Esparza, Rogelio;
- Liu, Kun-Wei;
- Edwards, Michael;
- Swartling, Fredrik J.;
- Sahoo, Debashis;
- Li, Gordon;
- Wechsler-Reya, Robert J.;
- Reimand, Jüri;
- Cho, Yoon-Jae;
- Taylor, Michael D.
Publication type:
Article
The oncogenic circular RNA circ_63706 is a potential therapeutic target in sonic hedgehog-subtype childhood medulloblastomas.
Published in:
Acta Neuropathologica Communications, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40478-023-01521-0
By:
- Katsushima, Keisuke;
- Pokhrel, Rudramani;
- Mahmud, Iqbal;
- Yuan, Menglang;
- Murad, Rabi;
- Baral, Prabin;
- Zhou, Rui;
- Chapagain, Prem;
- Garrett, Timothy;
- Stapleton, Stacie;
- Jallo, George;
- Bettegowda, Chetan;
- Raabe, Eric;
- Wechsler-Reya, Robert J.;
- Eberhart, Charles G.;
- Perera, Ranjan J.
Publication type:
Article
The long noncoding RNA lnc-HLX-2-7 is oncogenic in Group 3 medulloblastomas.
Published in:
Neuro-Oncology, 2021, v. 23, n. 4, p. 572, doi. 10.1093/neuonc/noaa235
By:
- Katsushima, Keisuke;
- Lee, Bongyong;
- Kunhiraman, Haritha;
- Zhong, Cuncong;
- Murad, Rabi;
- Yin, Jun;
- Liu, Ben;
- Garancher, Alexandra;
- Gonzalez-Gomez, Ignacio;
- Monforte, Hector L;
- Stapleton, Stacie;
- Vibhakar, Rajeev;
- Bettegowda, Chetan;
- Wechsler-Reya, Robert J;
- Jallo, George;
- Raabe, Eric;
- Eberhart, Charles G;
- Perera, Ranjan J
Publication type:
Article
Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma.
Published in:
Neuro-Oncology, 2021, v. 23, n. 2, p. 226, doi. 10.1093/neuonc/noaa191
By:
- Ecker, Jonas;
- Thatikonda, Venu;
- Sigismondo, Gianluca;
- Selt, Florian;
- Valinciute, Gintvile;
- Oehme, Ina;
- Müller, Carina;
- Buhl, Juliane L;
- Ridinger, Johannes;
- Usta, Diren;
- Qin, Nan;
- Tilburg, Cornelis M van;
- Herold-Mende, Christel;
- Remke, Marc;
- Sahm, Felix;
- Westermann, Frank;
- Kool, Marcel;
- Wechsler-Reya, Robert J;
- Chavez, Lukas;
- Krijgsveld, Jeroen
Publication type:
Article
STRUCTURAL VARIANTS SHUFFLE CHROMATIN TO ACTIVATE GFI1 FAMILY ONCOGENES IN MEDULLOBLASTOMA.
Published in:
Neuro-Oncology, 2014, v. 16, n. suppl_3, p. iii24
By:
- Northcott, Paul A.;
- Lee, Catherine;
- Zichner, Thomas;
- Lichter, Peter;
- Korbel, Jan O.;
- Wechsler-Reya, Robert J.;
- Pfister, Stefan M.
Publication type:
Article
HIGH-THROUGHPUT DRUG SCREENING IDENTIFIES HDAC INHIBITORS AS CANDIDATE THERAPEUTICS FOR MYC-DRIVEN MEDULLOBLASTOMA.
Published in:
Neuro-Oncology, 2014, v. 16, n. suppl_3, p. iii29, doi. 10.1093/neuonc/nou208.22
By:
- Wechsler-Reya, Robert J.;
- Pei, Yanxin;
- Liu, Kun-Wei;
- Wang, Jun;
- Esparza, Lourdes A.;
- Maier, Donna L.;
- Li, Xiao-Nan;
- Cho, Yoon-Jae
Publication type:
Article
A novel serum extracellular vesicle protein signature to monitor glioblastoma tumor progression.
Published in:
International Journal of Cancer, 2023, v. 152, n. 2, p. 308, doi. 10.1002/ijc.34261
By:
- Tzaridis, Theophilos;
- Weller, Johannes;
- Bachurski, Daniel;
- Shakeri, Farhad;
- Schaub, Christina;
- Hau, Peter;
- Buness, Andreas;
- Schlegel, Uwe;
- Steinbach, Joachim‐Peter;
- Seidel, Clemens;
- Goldbrunner, Roland;
- Schäfer, Niklas;
- Wechsler‐Reya, Robert J.;
- Hallek, Michael;
- Scheffler, Björn;
- Glas, Martin;
- Haeberle, Lothar;
- Herrlinger, Ulrich;
- Coch, Christoph;
- Reiners, Katrin S.
Publication type:
Article
Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma.
Published in:
PLoS ONE, 2019, v. 14, n. 9, p. 1, doi. 10.1371/journal.pone.0214901
By:
- Chahal, Kirti Kandhwal;
- Li, Jie;
- Kufareva, Irina;
- Parle, Milind;
- Durden, Donald L.;
- Wechsler-Reya, Robert J.;
- Chen, Clark C.;
- Abagyan, Ruben
Publication type:
Article
The long non-coding RNA SPRIGHTLY and its binding partner PTBP1 regulate exon 5 skipping of SMYD3 transcripts in group 4 medulloblastomas.
Published in:
Neuro-Oncology Advances, 2022, v. 4, n. 1, p. 1, doi. 10.1093/noajnl/vdac120
By:
- Bongyong Lee;
- Keisuke Katsushima;
- Pokhrel, Rudramani;
- Menglang Yuan;
- Stapleton, Stacie;
- Jallo, George;
- Wechsler-Reya, Robert J.;
- Eberhart, Charles G.;
- Ray, Animesh;
- Perera, Ranjan J.
Publication type:
Article
A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity.
Published in:
Nature Neuroscience, 2013, v. 16, n. 12, p. 1737, doi. 10.1038/nn.3553
By:
- Li, Peng;
- Du, Fang;
- Yuelling, Larra W;
- Lin, Tiffany;
- Muradimova, Renata E;
- Tricarico, Rossella;
- Wang, Jun;
- Enikolopov, Grigori;
- Bellacosa, Alfonso;
- Wechsler-Reya, Robert J;
- Yang, Zeng-jie
Publication type:
Article
Isolation of neural stem cells from the postnatal cerebellum.
Published in:
Nature Neuroscience, 2005, v. 8, n. 6, p. 723, doi. 10.1038/nn1473
By:
- Lee, Audra;
- Kessler, Jessica D.;
- Read, Tracy-Ann;
- Kaiser, Constanze;
- Corbeil, Denis;
- Huttner, Wieland B.;
- Johnson, Jane E.;
- Wechsler-Reya, Robert J.
Publication type:
Article
Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06564-9
By:
- Kahn, Suzana A.;
- Xin Wang;
- Nitta, Ryan T.;
- Gholamin, Sharareh;
- Theruvath, Johanna;
- Hutter, Gregor;
- Azad, Tej D.;
- Wadi, Lina;
- Bolin, Sara;
- Ramaswamy, Vijay;
- Esparza, Rogelio;
- Kun-Wei Liu;
- Edwards, Michael;
- Swartling, Fredrik J.;
- Sahoo, Debashis;
- Gordon Li;
- Wechsler-Reya, Robert J.;
- Reimand, Jüri;
- Yoon-Jae Cho;
- Taylor, Michael D.
Publication type:
Article
Stem Cells and the Origin and Propagation of Brain Tumors.
Published in:
Journal of Child Neurology, 2008, v. 23, n. 10, p. 1172, doi. 10.1177/0883073808321062
By:
- Emmenegger, Brian A.;
- Wechsler-Reya, Robert J.
Publication type:
Article
Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.
Published in:
Neuro-Oncology, 2022, v. 24, n. 2, p. 273, doi. 10.1093/neuonc/noab135
By:
- Riemondy, Kent A;
- Venkataraman, Sujatha;
- Willard, Nicholas;
- Nellan, Anandani;
- Sanford, Bridget;
- Griesinger, Andrea M;
- Amani, Vladimir;
- Mitra, Siddhartha;
- Hankinson, Todd C;
- Handler, Michael H;
- Sill, Martin;
- Ocasio, Jennifer;
- Weir, Seth J;
- Malawsky, Daniel S;
- Gershon, Timothy R;
- Garancher, Alexandra;
- Wechsler-Reya, Robert J;
- Hesselberth, Jay R;
- Foreman, Nicholas K;
- Donson, Andrew M
Publication type:
Article
Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
Published in:
Science Translational Medicine, 2022, v. 14, n. 626, p. 1, doi. 10.1126/scitranslmed.abf3917
By:
- Dixit, Deobrat;
- Prager, Briana C.;
- Gimple, Ryan C.;
- Miller, Tyler E.;
- Wu, Qiulian;
- Yomtoubian, Shira;
- Kidwell, Reilly L.;
- Lv, Deguan;
- Zhao, Linjie;
- Qiu, Zhixin;
- Zhang, Guoxin;
- Lee, Derrick;
- Park, Donglim Esther;
- Wechsler-Reya, Robert J.;
- Wang, Xiuxing;
- Bao, Shideng;
- Rich, Jeremy N.
Publication type:
Article
Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression.
Published in:
Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03654-9
By:
- Zagozewski, Jamie;
- Borlase, Stephanie;
- Guppy, Brent J.;
- Coudière-Morrison, Ludivine;
- Shahriary, Ghazaleh M.;
- Gordon, Victor;
- Liang, Lisa;
- Cheng, Stephen;
- Porter, Christopher J.;
- Kelley, Rhonda;
- Hawkins, Cynthia;
- Chan, Jennifer A.;
- Liang, Yan;
- Gong, Jingjing;
- Nör, Carolina;
- Saulnier, Olivier;
- Wechsler-Reya, Robert J.;
- Ramaswamy, Vijay;
- Werbowetski-Ogilvie, Tamra E.
Publication type:
Article

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