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- Title
Refractive and Vision Status in Down Syndrome: A Comparative Study.
- Authors
Hashemi, Hassan; Mehravaran, Shiva; Asgari, Soheila; Dehghanian Nasrabadi, Farzaneh
- Abstract
Objectives: To determine the prevalence of refractive errors and visual impairment in Down syndrome (DS) patients compared to normal controls. Materials and Methods: Cycloplegic refraction was tested in 213 DS patients and 184 normal age- and gender-matched controls using autorefraction followed by retinoscopy. Data from the worse eye of each case were used in the analyses. Results: In the DS and control groups, respectively, mean age was 17.2±4.8 and 17.2±4.4 years (p=0.993) and 53.0% and 49.5% were male (p=0.473). In the DS and control groups, respectively, mean spherical equivalent (SE) was -5.13±4.47 and -4.15±3.04 diopters (D) in myopics (p=0.050) and 2.47±1.64 and 2.36±2.04 D in hyperopics (p=0.482), mean cylinder error was -2.17±1.39 and -2.05±1.57 D (p=0.451), mean J0 was -0.03±0.89 and 0.12±0.76 D (p=0.086), and mean J45 was 0.11±1.02 and -0.13±1.03 D (p=0.024). The prevalence of oblique astigmatism was higher in the DS group (20.4% vs. 6.1%) while against-the-rule astigmatism was more prevalent in the control group (84.0% vs. 71.6%) (p<0.001). The prevalence of anisometropia was not significantly different between the groups (19.4% vs. 13.8%). Visual impairment was detected in 11.7% of the DS and 0.5% of the control group (p<0.001). The prevalence of amblyopia was 36.3% and 3.8% in the DS and control groups, respectively (p<0.001). Based on the multiple model, only absolute SE inversely correlated with age and differed between males and females (all p<0.05). Conclusion: In DS patients, the prevalence rates of refractive errors, amblyopia, and visual impairment are higher than those in non-DS individuals, and emmetropization appears to be either defective or slow. Cylinder error is stable in this age range, but the rotation of astigmatism axis is different from normal samples.
- Subjects
ASTIGMATISM; DOWN syndrome; AGE distribution; COMPARATIVE studies; SEX distribution; AMBLYOPIA; DESCRIPTIVE statistics; VISION disorders; REFRACTIVE errors
- Publication
Turkish Journal of Ophthalmology / Turk Oftalmoloji Dergisi, 2021, Vol 51, Issue 4, p199
- ISSN
1300-0659
- Publication type
Article
- DOI
10.4274/tjo.galenos.2020.52959