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- Title
Viral metagenomics of fecal samples from non-human primates revealed human astrovirus in a chimpanzee, China.
- Authors
Xiaochun Wang; Jinxin Wang; Chenglin Zhou; Shixing Yang; Quan Shen; Wen Zhang; Dunwu Qi
- Abstract
Background: Human astroviruses (HAstVs) are commonly identified worldwide as important aetiological agents of acute gastroenteritis in all age groups. More and more evidences challenged the paradigm that AstV infections are species-specific. Yet to date, AstVs associated with human infections have not been detected in any animal hosts. Results: Viral metagenomics methods were used to detect viral nucleic acids in fecal samples from 69 captive non-human primates (NHPs) from three zoos in China. Sequence reads showing high similarity to astrovirus MLB2 were found in feces from a chimpanzee with diarrhea. The complete genome of this astrovirus was determined and deposited in the GenBank under accession number KX273058 (named SAstV-nj). Phylogenetic analysis based on complete genomes revealed that SAstV-nj was closely related to and shared >98% nucleotide sequence identity with the previous human astrovirus MLB2 strains. Conclusions: This study suggested that MLB2-related astroviruses might have the potential of cross-species transmission between human and NHP.
- Subjects
METAGENOMICS; FECES examination; ANIMAL models of gastroenteritis; ASTROVIRUSES; CHIMPANZEES as laboratory animals
- Publication
Gut Pathogens, 2016, Vol 8, p1
- ISSN
1757-4749
- Publication type
Article
- DOI
10.1186/s13099-016-0140-2