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- Title
IL-2 Immunotherapy to Recently HIV-1 Infected Adults Maintains the Numbers of IL-17 Expressing CD4+ T (T17) Cells in the Periphery.
- Authors
Ndhlovu, Lishomwa C.; Sinclair, Elizabeth; Epling, Lorrie; Qi Xuan Tan; Ho, Terence; Jha, Aashish R.; Eccles-James, Ijeoma; Tincati, Camilla; Levy, Jay A.; Nixon, Douglas F.; Hecht, Frederick M.; Barbour, Jason D.
- Abstract
Little is known about the manipulation of IL-17 producing CD4+ T cells (T17) on a per-cell basis in humans in vivo. Previous studies on the effects of IL-2 on IL-17 secretion in non-HIV models have shown divergent results. We hypothesized that IL-2 would mediate changes in IL-17 levels among recently HIV-1-infected adults receiving anti-retroviral therapy. We measured cytokine T cell responses to CD3/CD28, HIV-1 Gag, and CMV pp65 stimulation, and changes in multiple CD4+ T cell subsets. Those who received IL-2 showed a robust expansion of naive and total CD4+ T cell counts and T-reg counts. However, after IL-2 treatment, the frequency of T17 cells declined, while counts of T17 cells did not change due to an expansion of the CD4+ naïve T cell population (CD27+CD45RA+). Counts of HIV-1 Gag-specific T cells declined modestly, but CMV pp65 and CD3/CD28 stimulated populations did not change. Hence, in contrast with recent studies, our results suggest IL-2 is not a potent in vivo regulator of T17 cell populations in HIV-1 disease. However, IL-2-mediated T-reg expansions may selectively reduce responses to certain antigen-specific populations, such as HIV-1 Gag.
- Subjects
T cells; HIV; INTERLEUKIN-2; CYTOKINES; ANTIRETROVIRAL agents; CLINICAL immunology
- Publication
Journal of Clinical Immunology, 2010, Vol 30, Issue 5, p681
- ISSN
0271-9142
- Publication type
Article
- DOI
10.1007/s10875-010-9432-3