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- Title
T Regulatory Cells in Autoimmune Diabetes: Past Challenges, Future Prospects.
- Authors
Jeffrey Bluestone; Qizhi Tang; Caitlin Sedwick
- Abstract
Abstract Introduction  Accumulating evidence suggests that defective regulation is an essential underlying cause of autoimmunity. The development of type 1 diabetes in the NOD mouse strain it is a complex process that depends on a fine balance between pathogenic and regulatory pathways. Discussion  We have utilized a series of transgenic and knockout mice to determine the relative importance of regulatory T cells and negative regulatory receptors on the development and progression of type 1 diabetes. Conclusion  This review will focus on the origins and function of Treg in peripheral self-tolerance. We will summarize the role of Treg in preventing autoimmune diseases, with a particular focus on Type 1 Diabetes (T1D), and discuss the prospects for Treg-based therapies for autoimmune diseases.
- Subjects
T cell receptors; DIABETES; AUTOIMMUNE disease prevention; AUTOIMMUNITY; LABORATORY mice; PATHOGENIC microorganisms
- Publication
Journal of Clinical Immunology, 2008, Vol 28, Issue 6, p677
- ISSN
0271-9142
- Publication type
Article
- DOI
10.1007/s10875-008-9242-z