We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A network of protein?protein interactions in yeast.
- Authors
Schwikowski, Benno; Uetz, Peter; Fields, Stanley
- Abstract
A global analysis of 2,709 published interactions between proteins of the yeast Saccharomyces cerevisiae has been performed, enabling the establishment of a single large network of 2,358 interactions among 1,548 proteins. Proteins of known function and cellular location tend to cluster together, with 63% of the interactions occurring between proteins with a common functional assignment and 76% occurring between proteins found in the same subcellular compartment. Possible functions can be assigned to a protein based on the known functions of its interacting partners. This approach correctly predicts a functional category for 72% of the 1,393 characterized proteins with at least one partner of known function, and has been applied to predict functions for 364 previously uncharacterized proteins.
- Subjects
PROTEIN binding; YEAST; GENOMICS
- Publication
Nature Biotechnology, 2000, Vol 18, Issue 12, p1257
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/82360