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- Title
The Effect of Specific Antibody on the Generation of Cytotoxic T Lymphocytes and the Recovery of Mice from Influenza Virus Infection.
- Authors
Yap, K. L.; Ada, G. L.
- Abstract
A study has been made of the effect of humoral antibody on the generation of specific cytotoxic T cells (Tc) in the spleen or lungs after intravenous injection or intranasal inoculation of infectious influenza virus. Antibody injected before or at the same time as virus inhibited completely the generation of Tc in the spleen. If injected I h after virus, the inhibition was reduced by 50% and little inhibition occurred if antibody was injected ft h after virus. This suggested that antibody failed to influence Tc generation once infection of stimulating cells had occurred. Antibody injected intravenously 24 h after intranasal inoculation of virus into normal mice did not affect the level of cytotoxic activity present in the lungs, and trace amounts only ( <1 log10 EID50) could be recovered from the lungs at 6 days. As there is a high titre (< 6 log10 EID50) of infectious virus in the lungs of mice 24 h alter infection, this represents a very efficient control mechanism. The same protocol curried out with athymic mice gave only a partial clearance (c. 3 log10 EID50) of virus in the lungs. It was suggested that a major role of humoral antibody was to limit infection by the virus, and in this respect it complemented the action of Tc.
- Subjects
LYMPHOCYTES; IMMUNOGLOBULINS; INTRAVENOUS injections; INFLUENZA viruses; RESPIRATORY infections; T cells
- Publication
Scandinavian Journal of Immunology, 1979, Vol 10, Issue 4, p325
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1979.tb01358.x