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- Title
Expression of FoxP3, a key molecule in CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells, in adult T-cell leukaemia/lymphoma cells.
- Authors
Karube, Kennosuke; Ohshima, Koichi; Tsuchiya, Takeshi; Yamaguchi, Takahiro; Kawano, Riko; Suzumiya, Junji; Utsunomiya, Atae; Harada, Mine; Kikuchi, Masahiro
- Abstract
Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive neoplastic disease that usually exhibits a CD4+CD25+ phenotype. Regulatory T cells (Treg), which suppress T-cell effector function, are characterized by the co-expression of CD4 and CD25. We analysed the expression of forkhead/ winged helix transcription factor (FoxP3), a specific marker that is important for the function of Treg, on ATLL cells from 17 patients (peripheral blood, n = 8; lymph node, n = 9). Real-time polymerase chain reaction and immunostaining detected FoxP3 expression in 10 ATLL cases, but was relatively down-regulated compared with Treg from normal subjects. These results indicate the association of ATLL and Treg.
- Subjects
TRANSCRIPTION factors; POLYMERASE chain reaction; LYMPHOCYTES; LYMPHOMAS; LEUKEMIA; HEMATOLOGY
- Publication
British Journal of Haematology, 2004, Vol 126, Issue 1, p81
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2004.04999.x