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- Title
Hypofibronectinaemia and severity of sickle cell anaemia in Nigeria.
- Authors
Emeribe, A. O.; Udoh, A. E.; Etukudoh, M. H.; Okany, C. C.; Kehinde, M.; Catty, D.; Raykundalia, C.
- Abstract
Plasma fibronectin levels in sickle cell anaemia and apparently healthy Nigerians were investigated to determine any correlation with disease severity. A cheaper in-house plasma fibronectin assay was also developed that could be adapted for use in Africa and elsewhere. Plasma fibronectin assay was concurrently carried out using the newly developed inhibition enzyme-linked immunosorbent assay (ELISA) and a commercial competitive binding ELISA. The in-house assay compared favourably with that of the commercial kit. The mean plasma fibronectin levels in sickle cell anaemia subjects were significantly lower than that of control subjects (P < 0·001). Plasma fibronectin concentration could therefore be useful in assessing the severity of sickle cell anaemia.
- Subjects
NIGERIA; FIBRONECTINS; BLOOD plasma; SICKLE cell anemia; NIGERIANS; HEALTH
- Publication
British Journal of Haematology, 2000, Vol 111, Issue 4, p1194
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2000.02445.x