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- Title
Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO<sub>2</sub>(mpETSC)] and [Pt(mpETSC)Cl].
- Authors
Elsayed, Shadia A.; El-Hendawy, Ahmed M.; Mostafa, Sahar I.; Jean-Claude, Bertrand J.; Todorova, Margarita; Butler, Ian S.
- Abstract
New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2- carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR (¹H, 13C, and 31P), and electronic spectral data. The X-ray crystal structures of [VO2 (mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl2] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).
- Subjects
ANTINEOPLASTIC agents; TRANSITION metals; METAL complexes; PYRIDINE; MOLECULAR structure; RUTHENIUM compounds; CANCER cells; NUCLEAR magnetic resonance spectroscopy
- Publication
Bioinorganic Chemistry & Applications, 2010, Vol 2010, p1
- ISSN
1565-3633
- Publication type
Article
- DOI
10.1155/2010/149149