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Astrocyte biomarkers GFAP and YKL‐40 mediate early Alzheimer's disease progression.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 1, p. 483, doi. 10.1002/alz.13450
By:
- Pelkmans, Wiesje;
- Shekari, Mahnaz;
- Brugulat‐Serrat, Anna;
- Sánchez‐Benavides, Gonzalo;
- Minguillón, Carolina;
- Fauria, Karine;
- Molinuevo, Jose Luis;
- Grau‐Rivera, Oriol;
- González Escalante, Armand;
- Kollmorgen, Gwendlyn;
- Carboni, Margherita;
- Ashton, Nicholas J.;
- Zetterberg, Henrik;
- Blennow, Kaj;
- Suarez‐Calvet, Marc;
- Gispert, Juan Domingo
Publication type:
Article
Pathophysiological mechanisms of grey matter morphometry changes in preclinical Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074804
By:
- Pelkmans, Wiesje;
- Cacciaglia, Raffaele;
- Salvadó, Gemma;
- Falcon, Carles;
- Minguillón, Carolina;
- Fauria, Karine;
- Kollmorgen, Gwendlyn;
- Carboni, Margherita;
- Molinuevo, Jose Luis;
- Grau‐Rivera, Oriol;
- Zetterberg, Henrik;
- Blennow, Kaj;
- Suarez‐Calvet, Marc;
- Gispert, Juan Domingo
Publication type:
Article
Different astrocyte phenotypes mediate the pathological cascade early in the Alzheimer's disease continuum.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074674
By:
- Pelkmans, Wiesje;
- Shekari, Mahnaz;
- Brugulat‐Serrat, Anna;
- Sánchez‐Benavides, Gonzalo;
- Minguillón, Carolina;
- Fauria, Karine;
- Molinuevo, Jose Luis;
- Grau‐Rivera, Oriol;
- González Escalante, Armand;
- Kollmorgen, Gwendlyn;
- Carboni, Margherita;
- Ashton, Nicholas J.;
- Zetterberg, Henrik;
- Blennow, Kaj;
- Suarez‐Calvet, Marc;
- Gispert, Juan Domingo
Publication type:
Article
Pathophysiological mechanisms of grey matter morphometry changes in preclinical Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081662
By:
- Pelkmans, Wiesje;
- Cacciaglia, Raffaele;
- Salvadó, Gemma;
- Falcon, Carles;
- Minguillón, Carolina;
- Fauria, Karine;
- Kollmorgen, Gwendlyn;
- Carboni, Margherita;
- Molinuevo, Jose Luis;
- Grau‐Rivera, Oriol;
- Zetterberg, Henrik;
- Blennow, Kaj;
- Suarez‐Calvet, Marc;
- Gispert, Juan Domingo
Publication type:
Article
Mechanisms linking hearing loss with risk for dementia depends on age.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.063805
By:
- van 't Hooft, Jochum J.;
- Pelkmans, Wiesje;
- Tomassen, Jori;
- Smits, Cas;
- Legdeur, Nienke;
- den Braber, Anouk;
- Barkhof, Frederik;
- van Berckel, Bart N.M.;
- Yaqub, Maqsood;
- Scheltens, Philip;
- Pijnenburg, Yolande A.L.;
- Visser, Pieter Jelle;
- Tijms, Betty M.
Publication type:
Article
Tau deposition is associated with grey matter network breakdown across different stages of the Alzheimer's disease continuum.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.050870
By:
- Pelkmans, Wiesje;
- Ossenkoppele, Rik;
- Dicks, Ellen;
- Strandberg, Olof;
- Barkhof, Frederik;
- Tijms, Betty M.;
- Pereira, Joana B.;
- Hansson, Oskar
Publication type:
Article
Amyloid‐β deposition in cognitively normal oldest‐old is associated with cortical thinning and faster memory decline: Imaging correlates of cognition and biomarkers.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042768
By:
- Pelkmans, Wiesje;
- Legdeur, Nienke;
- ten Kate, Mara;
- Yaqub, Maqsood;
- Barkhof, Frederik;
- Van Berckel, Bart N.M.;
- van Der Flier, Wiesje;
- Visser, Pieter Jelle;
- Tijms, Betty M.
Publication type:
Article
Amyloid‐β deposition in cognitively normal oldest‐old is associated with cortical thinning and faster memory decline: Neuroimaging: Neuroimaging predictors of cognitive decline.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.040991
By:
- Pelkmans, Wiesje;
- Legdeur, Nienke;
- Kate, Mara ten;
- Yaqub, Maqsood;
- Barkhof, Frederik;
- Van Berckel, Bart N.M.;
- van Der Flier, Wiesje;
- Visser, Pieter Jelle;
- Tijms, Betty M.
Publication type:
Article
Assessment of the appropriate use criteria for amyloid PET in an unselected memory clinic cohort: The ABIDE project.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, n. 11, p. 1458, doi. 10.1016/j.jalz.2019.07.003
By:
- de Wilde, Arno;
- Ossenkoppele, Rik;
- Pelkmans, Wiesje;
- Bouwman, Femke;
- Groot, Colin;
- van Maurik, Ingrid;
- Zwan, Marissa;
- Yaqub, Maqsood;
- Barkhof, Frederik;
- Lammertsma, Adriaan A.;
- Biessels, Geert Jan;
- Scheltens, Philip;
- van Berckel, Bart N.;
- van der Flier, Wiesje M.
Publication type:
Article
P3‐398: AMYLOID‐β IS ASSOCIATED WITH THINNER CORTEX IN COGNITIVELY NORMAL OLDEST‐OLD INDIVIDUALS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1104, doi. 10.1016/j.jalz.2019.06.3431
By:
- Pelkmans, Wiesje;
- Legdeur, Nienke;
- ten Kate, Mara;
- Yaqub, Maqsood M.;
- Van Berckel, Bart N.M.;
- Visser, Pieter Jelle;
- Tijms, Betty M.
Publication type:
Article
P2‐365: ADDED DIAGNOSTIC VALUE OF 18F‐FLUTEMETAMOL PET SCANNING IN YOUNG PATIENTS WITH DEMENTIA.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P740, doi. 10.1016/j.jalz.2019.06.2772
By:
- Handels, Ron;
- Zwan, Marissa D.;
- Pelkmans, Wiesje;
- Bouwman, Femke H.;
- Biessels, Geert Jan;
- Roks, Gerwin;
- Schoonenboom, Niki S.M.;
- Verwey, Nicolaas A.;
- Van Berckel, Bart N.M.;
- van der Flier, Wiesje M.;
- Verhey, Frans R.J.;
- Scheltens, Philip
Publication type:
Article
TD‐P‐25: DEVELOPMENT AND USABILITY OF ADAPPT: AN ONLINE TOOL TO SUPPORT CLINICIANS, PATIENTS AND CAREGIVERS IN THE DIAGNOSIS OF MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P163, doi. 10.1016/j.jalz.2019.06.4336
By:
- Van Maurik, Ingrid S.;
- Visser, Leonie N.C.;
- Pel-Littel, Ruth;
- van Buchem, Marieke;
- Zwan, Marissa D.;
- Kunneman, Marleen;
- Pelkmans, Wiesje;
- Bouwman, Femke H.;
- Minkman, Mirella;
- Schoonenboom, Niki S.M.;
- Scheltens, Philip;
- Smets, Ellen M.;
- van der Flier, Wiesje M.
Publication type:
Article
P1‐476: CORTICAL T1‐W/T2‐W RATIO VALUES ARE HIGHER IN ALZHEIMER'S DISEASE COMPARED TO CONTROLS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P506, doi. 10.1016/j.jalz.2018.06.486
By:
- Pelkmans, Wiesje;
- Dicks, Ellen;
- Barkhof, Frederik;
- Scheltens, Philip;
- Van der Flier, Wiesje M.;
- Tijms, Betty M.
Publication type:
Article
IC‐P‐187: CORTICAL T1‐W/T2‐W RATIO VALUES ARE HIGHER IN ALZHEIMER'S DISEASE COMPARED TO CONTROLS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P156, doi. 10.1016/j.jalz.2018.06.2254
By:
- Pelkmans, Wiesje;
- Dicks, Ellen;
- Barkhof, Frederik;
- Scheltens, Philip;
- Van der Flier, Wiesje M.;
- Tijms, Betty M.
Publication type:
Article
Gray matter T1‐w/T2‐w ratios are higher in Alzheimer's disease.
Published in:
Human Brain Mapping, 2019, v. 40, n. 13, p. 3900, doi. 10.1002/hbm.24638
By:
- Pelkmans, Wiesje;
- Dicks, Ellen;
- Barkhof, Frederik;
- Vrenken, Hugo;
- Scheltens, Philip;
- Flier, Wiesje M.;
- Tijms, Betty M.
Publication type:
Article
CONCORDANCE BETWEEN CEREBROSPINAL FLUID AMYLOID-β AND [18F]FLORBETABEN PET IN AN UNSELECTED COHORT OF MEMORY CLINIC PATIENTS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P688, doi. 10.1016/j.jalz.2017.06.858
By:
- de Wilde, Arno;
- van der Flier, Wiesje M.;
- Bouwman, Femke H.;
- Ossenkoppele, Rik;
- Pelkmans, Wiesje;
- Groot, Colin;
- Zwan, Marissa D.;
- Yaqub, Maqsood M.;
- Teunissen, Charlotte E.;
- Stephens, Andrew;
- Lammertsma, Adriaan A.;
- van Berckel, Bart N.M.;
- Scheltens, Philip
Publication type:
Article
THE IMPACT OF AMYLOID PET ON DIAGNOSIS AND PATIENT MANAGEMENT IN AN UNSELECTED MEMORY CLINIC COHORT: THE ABIDE PROJECT.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1474, doi. 10.1016/j.jalz.2017.08.004
By:
- de Wilde, Arno;
- Pelkmans, Wiesje;
- Bouwman, Femke H.;
- Verwer, Jurre;
- Groot, Colin;
- van Buchem, Marieke;
- Zwan, Marissa D.;
- Ossenkoppele, Rik;
- Yaqub, Maqsood M.;
- Kunneman, Marleen;
- Smets, Ellen M.;
- Barkhof, Frederik;
- Lammertsma, Adriaan A.;
- Stephens, Andrew;
- van Lier, Erik;
- Biessels, Geert Jan;
- van Berckel, Bart N.M.;
- van der Flier, Wiesje M.;
- Scheltens, Philip
Publication type:
Article
CONCORDANCE BETWEEN CEREBROSPINAL FLUID AMYLOID-β AND [18F]FLORBETABEN PET IN AN UNSELECTED COHORT OF MEMORY CLINIC PATIENTS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P13, doi. 10.1016/j.jalz.2017.06.2277
By:
- de Wilde, Arno;
- van der Flier, Wiesje M.;
- Bouwman, Femke H.;
- Ossenkoppele, Rik;
- Pelkmans, Wiesje;
- Groot, Colin;
- Zwan, Marissa D.;
- Yaqub, Maqsood M.;
- Teunissen, Charlotte E.;
- Stephens, Andrew;
- Lammertsma, Adriaan A.;
- van Berckel, Bart N.M.;
- Scheltens, Philip
Publication type:
Article
CLINICAL AND RADIOLOGICAL FINDINGS IN PATIENTS WITH PATHOLOGICALLY CONFIRMED CAA.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1127, doi. 10.1016/j.jalz.2017.06.1639
By:
- Leijenaar, Jolien F.;
- Pelkmans, Wiesje;
- Rozemuller, Annemieke;
- Bouwman, Femke H.;
- van der Flier, Wiesje M.;
- Scheltens, Philip;
- Barkhof, Frederik;
- Prins, Niels D.
Publication type:
Article
THE DIAGNOSTIC VALUE OF AMYLOID PET IN AN UNSELECTED COHORT OF MEMORY CLINIC PATIENTS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P534, doi. 10.1016/j.jalz.2016.06.1047
By:
- de Wilde, Arno;
- van der Flier, Wiesje M.;
- Bouwman, Femke H.;
- Ossenkoppele, Rik;
- Pelkmans, Wiesje;
- Groot, Colin;
- Zwan, Marissa D.;
- Yaqub, Maqsood M.;
- Newman, Vanessa;
- Lammertsma, Adriaan A.;
- van Berckel, Bart N.M.;
- Scheltens, Philip
Publication type:
Article
THE DIAGNOSTIC VALUE OF AMYLOID PET IN AN UNSELECTED COHORT OF MEMORY CLINIC PATIENTS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P19, doi. 10.1016/j.jalz.2016.06.021
By:
- de Wilde, Arno;
- van der Flier, Wiesje M.;
- Bouwman, Femke H.;
- Ossenkoppele, Rik;
- Pelkmans, Wiesje;
- Groot, Colin;
- Zwan, Marissa D.;
- Yaqub, Maqsood M.;
- Newman, Vanessa;
- Lammertsma, Adriaan A.;
- van Berckel, Bart N.M.;
- Scheltens, Philip
Publication type:
Article
Is the association between blood pressure and cognition in the oldest-old modified by physical, vascular or brain pathology markers? The EMIF-AD 90 + Study.
Published in:
BMC Geriatrics, 2023, v. 23, n. 1, p. 1, doi. 10.1186/s12877-023-04440-w
By:
- Legdeur, Nienke;
- Moonen, Justine E.;
- Badissi, Maryam;
- Sudre, Carole H.;
- Pelkmans, Wiesje;
- Gordon, Mark Forrest;
- Barkhof, Frederik;
- Peters, Mike;
- Visser, Pieter Jelle;
- Muller, Majon
Publication type:
Article
Association of Amyloid Positron Emission Tomography With Changes in Diagnosis and Patient Treatment in an Unselected Memory Clinic Cohort: The ABIDE Project.
Published in:
JAMA Neurology, 2018, v. 75, n. 9, p. 1062, doi. 10.1001/jamaneurol.2018.1346
By:
- de Wilde, Arno;
- van der Flier, Wiesje M.;
- Pelkmans, Wiesje;
- Bouwman, Femke;
- Verwer, Jurre;
- Groot, Colin;
- van Buchem, Marieke M.;
- Zwan, Marissa;
- Ossenkoppele, Rik;
- Yaqub, Maqsood;
- Kunneman, Marleen;
- Smets, Ellen M. A.;
- Barkhof, Frederik;
- Lammertsma, Adriaan A.;
- Stephens, Andrew;
- van Lier, Erik;
- Biessels, Geert Jan;
- van Berckel, Bart N.;
- Scheltens, Philip
Publication type:
Article
Amyloid‐β, cortical thickness, and subsequent cognitive decline in cognitively normal oldest‐old.
Published in:
Annals of Clinical & Translational Neurology, 2021, v. 8, n. 2, p. 348, doi. 10.1002/acn3.51273
By:
- Pelkmans, Wiesje;
- Legdeur, Nienke;
- Kate, Mara;
- Barkhof, Frederik;
- Yaqub, Maqsood M.;
- Holstege, Henne;
- Berckel, Bart N. M.;
- Scheltens, Philip;
- Flier, Wiesje M.;
- Visser, Pieter Jelle;
- Tijms, Betty M.
Publication type:
Article
Grey matter network markers identify individuals with prodromal Alzheimer's disease who will show rapid clinical decline.
Published in:
Brain Communications, 2022, v. 4, n. 2, p. 1, doi. 10.1093/braincomms/fcac026
By:
- Pelkmans, Wiesje;
- Vromen, Ellen M.;
- Dicks, Ellen;
- Scheltens, Philip;
- Teunissen, Charlotte E.;
- Barkhof, Frederik;
- van der Flier, Wiesje M.;
- Tijms, Betty M.
Publication type:
Article
Tau-related grey matter network breakdown across the Alzheimer's disease continuum.
Published in:
Alzheimer's Research & Therapy, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13195-021-00876-7
By:
- Pelkmans, Wiesje;
- Ossenkoppele, Rik;
- Dicks, Ellen;
- Strandberg, Olof;
- Barkhof, Frederik;
- Tijms, Betty M.;
- Pereira, Joana B.;
- Hansson, Oskar
Publication type:
Article

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