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CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia.
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- Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01204-8
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- Article
Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.
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- EMBO Molecular Medicine, 2013, v. 5, n. 4, p. 608, doi. 10.1002/emmm.201202215
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- Publication type:
- Article
Nonsteroidal Anti-Inflammatory Drugs and Peroxisome Proliferator-Activated Receptor-γ Agonists Modulate Immunostimulated Processing of Amyloid Precursor Protein through Regulation of Β...
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- Journal of Neuroscience, 2003, v. 23, n. 30, p. 9796, doi. 10.1523/JNEUROSCI.23-30-09796.2003
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- Publication type:
- Article
Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: A systematic review.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 12, p. 5885, doi. 10.1002/alz.13412
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- Publication type:
- Article
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding.
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- 2007
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- Publication type:
- journal article
IDENTIFICATION OF NOVEL TARGETS FOR INHIBITING PRION-LIKE SEEDING AND PROPAGATION OF TAU PATHOLOGY IN VITRO AND IN VIVO.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1270, doi. 10.1016/j.jalz.2017.06.1901
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- Publication type:
- Article
MOLECULAR MECHANISMS OF ABETA-INDUCED TAU-PATHOLOGY: ANALYSIS OF CROSS-SEEDING OF ABETA AND TAU AND ITS ROLE IN PRION-LIKE PROPAGATION OF TAU-PATHOLOGY IN VITRO AND IN VIVO.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P385, doi. 10.1016/j.jalz.2016.06.722
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- Publication type:
- Article
IDENTIFICATION AND VALIDATION OF TAU-MODIFIERS, IDENTIFIED BY UNBIASED GENOME WIDE APPROACHES, USING AAV-BASED APPROACHES IN TAU TRANSGENIC MICE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P845, doi. 10.1016/j.jalz.2016.06.1730
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- Publication type:
- Article
Study of spontaneous seizure in a mouse model of Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P888, doi. 10.1016/j.jalz.2015.08.099
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- Publication type:
- Article
Amyloid precursor protein regulates neuronal cholesterol turnover needed for synaptic activity
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- 2012
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- Abstract
Identification of the tau interactome in mouse brain
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- 2011
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- Abstract
The amyloid-GSK3-tau connection to neurodegeneration revealed by combining transgenic and viral models
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- 2009
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- Abstract
P4-190: Role of gamma-secretase in lipoprotein endocytosis
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- 2008
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- Publication type:
- Abstract
P1-039: Dendritic defects in transgenic mice that model various aspects of Alzheimer's disease
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- 2008
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- Abstract
P1-005: AAV-based paradigm for amyloid and Tau pathology as in vivo model for Alzheimer's disease
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- 2008
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- Publication type:
- Abstract
O4-01-08: Neurodegeneration and neuroinflammation in cdk5/p25 inducible mice: A model for hippocampal sclerosis and neocortical degeneration
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- 2008
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- Publication type:
- Abstract
O4-01-01: Analysis of the metabolism of amyloid precursor protein and of protein tau in mice with neuron-specific postnatal deficiency of Gsk3β
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- 2008
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- Publication type:
- Abstract
O2-02-05: Amyloid causes tauopathy by activating GSK3
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- 2008
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- Publication type:
- Abstract
P1-063: Deregulation of NMDA-receptor function and signaling in APP[V717O] transgenic mice
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- 2006
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- Publication type:
- Abstract
O3-03-08: Differential effects of presenilin-1 deficiency and mutant presenilin-1 on synaptic plasticity
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- 2006
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- Publication type:
- Abstract
O2-04-01: Combined amyloid and tau-pathology in APPV717I X taup301L double transgenic mice: Increased survival correlates with less hindbrain pathology, despite dramatic forebrain tauopathy
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- 2006
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- Publication type:
- Abstract
P1-063: Deregulation of NMDA-receptor function and signaling in APP[V717O] transgenic mice
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- 2006
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- Publication type:
- Abstract
O3-03-08: Differential effects of presenilin-1 deficiency and mutant presenilin-1 on synaptic plasticity
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- 2006
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- Publication type:
- Abstract
O2-04-01: Combined amyloid and tau-pathology in APPV717I X taup301L double transgenic mice: Increased survival correlates with less hindbrain pathology, despite dramatic forebrain tauopathy
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- 2006
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- Publication type:
- Abstract
Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells.
- Published in:
- Frontiers in Aging Neuroscience, 2016, p. 1, doi. 10.3389/fnagi.2016.00107
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- Publication type:
- Article
AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice.
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- PLoS ONE, 2009, v. 4, n. 10, p. 1, doi. 10.1371/journal.pone.0007280
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- Publication type:
- Article
What is the evidence that tau pathology spreads through prion-like propagation?
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- Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0488-7
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- Publication type:
- Article
Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis.
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- Journal of Neuroscience, 2008, v. 28, n. 46, p. 12094, doi. 10.1523/JNEUROSCI.2635-08.2008
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- Publication type:
- Article
Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice.
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- Journal of Neuroinflammation, 2005, v. 2, p. 22, doi. 10.1186/1742-2094-2-22
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- Publication type:
- Article
Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models.
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- Acta Neuropathologica Communications, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40478-024-01748-5
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- Publication type:
- Article
Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study.
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- JAMA Neurology, 2019, v. 76, n. 8, p. 915, doi. 10.1001/jamaneurol.2019.1424
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- Article
Axonal transport, tau protein, and neurodegeneration in Alzheimer’s disease.
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- NeuroMolecular Medicine, 2002, v. 2, n. 2, p. 151, doi. 10.1385/NMM:2:2:151
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- Publication type:
- Article
Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice.
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- Brain: A Journal of Neurology, 2005, v. 128, n. 6, p. 1442, doi. 10.1093/brain/awh452
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- Publication type:
- Article
APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation.
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- FASEB Journal, 2016, v. 30, n. 5, p. 1696, doi. 10.1096/fj.15-278739
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- Article
Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.
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- FASEB Journal, 2014, v. 28, n. 6, p. 2620, doi. 10.1096/fj.13-246702
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- Publication type:
- Article
Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice.
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- FASEB Journal, 2011, v. 25, n. 9, p. 3208, doi. 10.1096/fj.10-180133
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- Publication type:
- Article
Tau association with synaptic vesicles causes presynaptic dysfunction.
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- Nature Communications, 2017, v. 8, n. 5, p. 15295, doi. 10.1038/ncomms15295
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- Publication type:
- Article
Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.
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- Molecular Brain, 2013, v. 6, n. 1, p. 1, doi. 10.1186/1756-6606-6-27
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- Publication type:
- Article
Blood-based Aβ42 increases in the earliest pre-pathological stage before decreasing with progressive amyloid pathology in preclinical models and human subjects: opening new avenues for prevention.
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- Acta Neuropathologica, 2022, v. 144, n. 3, p. 489, doi. 10.1007/s00401-022-02458-9
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- Publication type:
- Article
Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo.
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- Acta Neuropathologica, 2019, v. 137, n. 4, p. 599, doi. 10.1007/s00401-018-01957-y
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- Publication type:
- Article
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.
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- Acta Neuropathologica, 2017, v. 133, n. 5, p. 731, doi. 10.1007/s00401-016-1663-9
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- Publication type:
- Article
Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.
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- Acta Neuropathologica, 2016, v. 131, n. 4, p. 549, doi. 10.1007/s00401-015-1525-x
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- Publication type:
- Article
Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.
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- Acta Neuropathologica, 2015, v. 129, n. 6, p. 875, doi. 10.1007/s00401-015-1413-4
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- Publication type:
- Article
GSK-3?/? kinases and amyloid production in vivo.
- Published in:
- Nature, 2011, v. 480, n. 7376, p. E4, doi. 10.1038/nature10615
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- Publication type:
- Article
Models of beta-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism.
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- Molecular Neurodegeneration, 2014, v. 9, n. 1, p. 155, doi. 10.1186/1750-1326-9-51
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- Publication type:
- Article
Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease.
- Published in:
- 2016
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- Publication type:
- journal article
The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model.
- Published in:
- Glia, 2022, v. 70, n. 6, p. 1117, doi. 10.1002/glia.24160
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- Publication type:
- Article
Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-41399-4
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- Publication type:
- Article
Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing.
- Published in:
- FEBS Open Bio, 2015, v. 5, p. 763, doi. 10.1016/j.fob.2015.09.002
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- Publication type:
- Article
Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.
- Published in:
- Frontiers in Physiology, 2017, p. 1, doi. 10.3389/fphys.2017.00796
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- Publication type:
- Article