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- Title
The Antitumor Effects in vitro of Sesquiterpene Lactones from Elephantopus scaber.
- Authors
LIANG Qiao-li; GONG Zhu-nan; XU Guang-lin; ZHAO Ye
- Abstract
The antitumor effects of sesquiterpene lactones scabertopin and isodexyelephnatopin from the whole plant of Elephantopus scaber were studied in vitro on SMMC-7721, Held and Caco-2 cancer cell lines. In MTT assay, scabertopin and isedexyelephantopin at the dose of 1-100 µM markedly inhibited the growth of three cancer cell lines in dose-dependent manner. The IC50 value of scabertopin and isodexyelephantopin on SMMC-7721 cells after 48 h of treatment were 29.27 and 9.54 µM, respectively, with their IC50 value on Held cells of 22.19 and 25.39 µM and on Caco-2 cells of 35.99 and 25.76 µM, The time-effect experiment also showed that isodexyelephantopin inhibited the growth of Held cells in time-dependent manner. DNA agarose gel electrophoresis of Held cells revealed obvious nuclear fragmentation (DNA ladder) treated with isodexyelephantopin for 48 h, which suggested the compound could induce the apoptosis of Held cell.
- Subjects
SESQUITERPENE lactones; PLANTS; CANCER cells; GEL electrophoresis; NUCLEAR fragmentation; APOPTOSIS
- Publication
Natural Product Research & Development, 2008, Vol 20, Issue 3, p436
- ISSN
1001-6880
- Publication type
Article