We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Diagnostic Value of <sup>18</sup>F-FDG PET/CT Scan in Characterizing Adrenal Tumors.
- Authors
Schaafsma, Merit; Berends, Annika M. A.; Links, Thera P.; Brouwers, Adrienne H.; Kerstens, Michiel N.
- Abstract
Context: Imaging plays an important role in the characterization of adrenal tumors, but findings might be inconclusive. The clinical question is whether 18F fluodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is of diagnostic value in this setting. Objective: This meta-analysis was aimed at the diagnostic value of 18F-FDG PET/CT in differentiating benign from malignant adrenal tumors discovered either as adrenal incidentaloma or during staging or follow-up of oncologic patients. Data sources: PubMed, EMBASE, Web of Science, and Cochrane Library were searched to select articles between 2000 and 2021. Study selection: We included studies describing the diagnostic value of 18F-FDG PET/CT in adult patients with an adrenal tumor. Exclusion criteria were 10 or fewer participants, insufficient data on histopathology, clinical follow-up, or PET results. After screening of title and abstract by 2 independent reviewers, 79 studies were retrieved, of which 17 studies met the selection criteria. Data extraction: Data extraction using a protocol and quality assessment according to QUADAS-2 was performed independently by at least 2 authors. Data synthesis: A bivariate random-effects model was applied using R (version 3.6.2.). Pooled sensitivity and specificity of 18F-FDG PET/CT for identifying malignant adrenal tumors was 87.3% (95% CI, 82.5%-90.9%) and 84.7% (95% CI, 79.3%-88.9%), respectively. The pooled diagnostic odds ratio was 9.20 (95% CI, 5.27-16.08; P < .01). Major sources of heterogeneity (I², 57.1% [95% CI, 27.5%-74.6%]) were in population characteristics, reference standard, and interpretation criteria of imaging results. Conclusions: 18F-FDG PET/CT had good diagnostic accuracy for characterization of adrenal tumors. The literature, however, is limited, in particular regarding adrenal incidentalomas. Large prospective studies in well-defined patient populations with application of validated cutoff values are needed.
- Subjects
POSITRON emission tomography computed tomography; ADRENAL tumors; PUBMED (Online service)
- Publication
Journal of Clinical Endocrinology & Metabolism, 2023, Vol 108, Issue 9, p2435
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/clinem/dgad138