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- Title
Progesterone Receptor Status of Epithelial Cells as a Predictive Marker for Postoperative Recurrence of Endometriosis.
- Authors
Yosuke Tarumi; Taisuke Mori; Koki Shimura; Yuko Izumi; Hiroyuki Okimura; Hisashi Kataoka; Tetsuya Kokabu; Fumitake Ito; Akemi Koshiba; Khan, Khaleque N.; Izumi Kusuki; Jo Kitawaki
- Abstract
Context: Progesterone resistance including progesterone receptor (PR) deficiency contributes to the pathophysiology of endometriosis; however, whether the PR expression levels in ovarian endometrioma (OE) correlate with the postoperative recurrence of endometriosis remains unclear. Objective: This study aimed to investigate the association between PR expression levels in OE and the recurrence of endometriosis. Methods: OE specimens were obtained from 132 patients who underwent conservative surgery for endometriosis. The PR expression levels were evaluated using the H score after immunohistochemical staining. Results: Of the 132 patients, 36 (27.3%) experienced recurrence and 96 (72.7%) did not. No differences were observed in the patient characteristics between the recurrence and nonrecurrence groups except for follow-up period. PR immunoreactivity in the epithelial cells (ECs) was statistically significantly lower in the recurrent group than in the nonrecurrent group (P < .01); however, this change was not observed in the stromal cells. Moreover, multivariable logistic regression analysis revealed that the H score of PR in ECs was an independent factor and was statistically significantly associated with the recurrence of endometriosis (P = .01). Furthermore, we divided the patients into PR-negative or PR-positive groups. The cumulative recurrence rate in the negative PR group was statistically significantly higher than that in the positive PR group (P = .046). Conclusion: Low PR expression levels in OE-ECs may predict the recurrence of endometriosis. The PR status in OE-ECs is associated with the pathophysiology of the recurrence of endometriosis, and optimized postoperative management for endometriosis may be provided by referring to the PR status.
- Subjects
PROGESTERONE receptors; EPITHELIAL cells; ENDOMETRIOSIS
- Publication
Journal of Clinical Endocrinology & Metabolism, 2022, Vol 107, Issue 6, p1552
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/clinem/dgac118