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- Title
White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats.
- Authors
Yong-Zhuo Liang; Hai-Ming Chen; Zu-Qing Su; Shao-Zhen Hou; Xiao-Ying Chen; Yi-Feng Zheng; Yu-Cui Li; Ji Lin; Janis Ya-Xian Zhan; Zi-Ren Su; Lu-Di Fu
- Abstract
This study attempted to explore the effects of white pepper and its major component piperine on puerarin administered to rats. Pharmacokinetic parameters of puerarin in rats were determined by oral administration (400mg/kg) or intravenous injection (40mg/kg) of puerarin, pretreated with or without white pepper and piperine given orally. Compared to the control group given oral puerarin only, the combined use of piperine (10 or 20mg/kg) increased the Cmax of puerarin by 1.30-fold or 1.64-fold and the AUC0-∞ by 133% or 157%, respectively. In contrast, coadministration of white pepper (125 or 250mg/kg) decreased oral absorption of puerarin to 83% or 74%, respectively. On the other hand, pretreatment with piperine orally did not alter the intravenous pharmacokinetics of puerarin, while the AUC of puerarin after intravenous administration was increased by pretreatment with white pepper. The results indicate that pretreatment with piperine or pepper exerts different effects on pharmacokinetics of puerarin administrated via intragastric and intravenous routes. Therefore, it is suggested that the combined application of piperine or white pepper with puerarin should be carefully monitored for potential diet-drug interactions.
- Subjects
CHINA; ALTERNATIVE medicine; ANIMAL experimentation; BIOAVAILABILITY; BIOPHYSICS; COMPARATIVE studies; DRUG synergism; DRUG-food interactions; HIGH performance liquid chromatography; INTRAVENOUS injections; INTESTINAL absorption; RESEARCH methodology; MEDICINAL plants; ORAL drug administration; PROBABILITY theory; RATS; RESEARCH funding; SPICES; STATISTICAL hypothesis testing; T-test (Statistics); PLANT extracts; ISOFLAVONES; DESCRIPTIVE statistics
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2014, Vol 2014, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2014/796890