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- Title
Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea.
- Authors
Lee, Seung Hun; Lee, Jae Hoon; Park, Sungdo; Lee, Hae Kyung; Do Hwang, Seon; Jeong, Hye Won; Heo, Jung Yeon; Lee, Yeong Seon
- Abstract
<bold>Background: </bold>The number of human Q fever cases in South Korea has been rapidly increasing since 2015. We report the first isolation of Coxiella burnetii in Korea in two patients who initially presented with non-specific febrile illness and were finally diagnosed with acute Q fever in South Korea.<bold>Case Presentation: </bold>Two adult patients with fever had serologic tests against C. burnetii initially negative, and polymerase chain reaction against 16S rRNA using whole blood was also negative. After bacterial amplification of C. burnetii in immune-depressed mice, we isolated C. burnetii from patients with acute Q fever. The isolates KZQ2 and KZQ3 were confirmed by polymerase chain reaction, nucleotide sequence analysis, and morphologic observation using a transmission electron microscope.<bold>Conclusions: </bold>These results can help us understand the clinical and epidemiologic features of Q fever in South Korea.
- Subjects
SOUTH Korea; Q fever; COXIELLA burnetii; RNA sequencing; TRANSMISSION electron microscopes; POLYMERASE chain reaction; DISEASES
- Publication
BMC Infectious Diseases, 2020, Vol 20, Issue 1, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-020-05130-3