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- Title
Cell-in-cell phenomenon associates with aggressive characteristics and cancer-related mortality in early oral tongue cancer.
- Authors
Almangush, Alhadi; Mäkitie, Antti A.; Hagström, Jaana; Haglund, Caj; Kowalski, Luiz Paulo; Nieminen, Pentti; Coletta, Ricardo D.; Salo, Tuula; Leivo, Ilmo
- Abstract
<bold>Background: </bold>Cell-in-cell structures (caused by cell cannibalistic activity) have been related to prognosis of many cancers. This is the first multi-institutional study to assess the prognostic impact of cell-in-cell structures in a large cohort of early oral tongue squamous cell carcinomas (OTSCC).<bold>Methods: </bold>A total of 308 cases from five Finnish University Hospitals and from the A.C. Camargo Cancer Center, São Paulo, Brazil, were included in this study. Cell-in-cell structures were evaluated on surgical postoperative sections that stained with hematoxylin and eosin staining.<bold>Results: </bold>We found that cell-in-cell structures associated with cancer-related mortality in univariable analysis with a hazard ratio (HR) of 2.99 (95%CI 1.52-5.88; P = 0.001). This association was confirmed in multivariable analysis (HR 2.22, 95%CI 1.12-4.44; P = 0.024). In addition, statistically significant associations were observed between the cell-in-cell structures and other adverse histopathologic characteristics including deep invasion (P < 0.001), high index of tumor budding (P = 0.007), worst pattern of invasion (P < 0.001), perineural invasion (P = 0.01), and stroma-rich pattern (P = 0.001).<bold>Conclusions: </bold>Our findings demonstrate a significant relationship between cell-in-cell formation and aggressive characteristics of early OTSCC. Cell-in-cell structures have a distinct impact as a novel prognostic indicator in early OTSCC and they can be easily assessed during routine pathology practice.
- Subjects
SAO Paulo (Brazil); FINLAND; BRAZIL; CANCER-related mortality; TONGUE cancer; ORAL cancer; TUMOR budding; GLOSSECTOMY; SQUAMOUS cell carcinoma; IMPACT craters; RESEARCH; TONGUE tumors; CANCER invasiveness; RESEARCH methodology; CELL physiology; PROGNOSIS; MEDICAL cooperation; EVALUATION research; TUMOR classification; COMPARATIVE studies; KAPLAN-Meier estimator; IMPACT of Event Scale; PROPORTIONAL hazards models; LONGITUDINAL method
- Publication
BMC Cancer, 2020, Vol 20, Issue 1, pN.PAG
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-020-07342-x