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- Title
Assessment of Adherence Measures with Different Stimulants Among Children and Adolescents.
- Authors
Sanchez, Robert J.; Crismon, M. Lynn; Barner, Jamie C.; Bettinger, Tawny; Wilson, James P.
- Abstract
Study Objective. To examine adherence measures with different stimulants in children and adolescents. Design. Retrospective analysis. Data Source. Texas Medicaid prescription claims database. Patients. A total of 9549 patients aged 5-18 years with attention-deficit-hyperactivity disorder. Measurements and Main Results. Paid prescription claims for newly started stimulants during the 2001-2002 school year were extracted from a database; 28,344 prescriptions (9549 patients) were available for analysis. Adherence was evaluated based on the drug therapy prescribed (i.e., mixed amphetamine salts, immediate-release methylphenidate, and extended-release methylphenidate-OROS [oral-osmotic formulation]) and the age and sex of the patient. Adherence measures were persistence and medication possession ratio (MPR). Persistence was higher for extended-release methylphenidate-OROS (0.50 ± 0.33) than for mixed amphetamine salts (0.42 ± 0.29) or immediate-release methylphenidate (0.37 ± 0.26; p<0.001). The MPR was also higher for extended-release methylphenidate-OROS (0.76 ± 0.37) than for mixed amphetamine salts (0.73 ± 0.37) or immediate-release methylphenidate (0.69 ± 0.37; p<0.001). Patients aged 5-9 years had equal or better persistence and MPR than those aged 10-14 and 15-18 years (p<0.001). No sex-related differences in adherence were observed. Conclusion. Adherence measures in our study were low. Although they were significantly better for extended-release methylphenidate-OROS than the other stimulants, the clinical significance of these differences are unclear. Further research should be conducted regarding pharmaceutical products, administration methods, and clinical interventions that may enhance adherence.
- Subjects
ATTENTION-deficit hyperactivity disorder; AMPHETAMINES; BEHAVIOR disorders in children; APPETITE depressants; PHENETHYLAMINES; STIMULANTS
- Publication
Pharmacotherapy, 2005, Vol 25, Issue 7, p909
- ISSN
0277-0008
- Publication type
Article
- DOI
10.1592/phco.2005.25.7.909