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- Title
Conformation-Specific Circular Dichroism Spectroscopy of Cold, Isolated Chiral Molecules.
- Authors
Hong, Aram; Choi, Chang Min; Eun, Han Jun; Jeong, Changseop; Heo, Jiyoung; Kim, Nam Joon
- Abstract
The CD spectroscopy of a chiral compound in solution yields an average CD value derived from all of the conformations of a chiral molecule. By contrast, CD spectroscopy of cold chiral molecules in the gas phase distinguishes specific conformers of a chiral molecule, but the weak CD effect has limited the practical application of this technique. Reported herein is the first resonant two-photon ionization CD spectra of ephedrines in a supersonic jet using circularly polarized laser pulses, which were generated by synchronizing the oscillation of the photoelastic modulator with the laser firing. The spectra exhibited well-resolved CD bands which were specific for the conformations and vibrational modes of each enantiomer. The CD signs and magnitudes of the jet-cooled chiral molecules were very sensitive to their conformations and thus offered crucial information for determining the three-dimensional structures of chiral species, as conducted in combination with quantum chemical calculations.
- Subjects
CIRCULAR dichroism; CONFORMATIONAL analysis; CHIRALITY; PHOTOIONIZATION; EPHEDRINE; LASER pulses; QUANTUM chemistry
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 30, p7939
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201403916