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- Title
Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans.
- Authors
Marakalala, Mohlopheni J.; Kerrigan, Ann M.; Brown, Gordon D.
- Abstract
The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
- Subjects
MYCOSES; GENETIC polymorphisms; ANTIFUNGAL agents; IMMUNITY; COMMUNICABLE diseases; POPULATION genetics
- Publication
Mammalian Genome, 2011, Vol 22, Issue 1/2, p55
- ISSN
0938-8990
- Publication type
Article
- DOI
10.1007/s00335-010-9277-3