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- Title
Differential Radio-Tolerance of Nutrition-Induced Morphotypes of Deinococcus radiodurans R1.
- Authors
Shukla, Sudhir; Gomathi Sankar, G.; Paraneeiswaran, A.; Subba Rao, T.
- Abstract
Deinococcus radiodurans R1 is a highly radio-tolerant bacterium. Depending on the nutrient availability D. radiodurans R1 exists in three morphologies viz. monococcal, diplococcal and tetracoccal. In this study, we examined whether nutrition-induced morphotypes of D. radiodurans showed similar DNA damage upon gamma radiation exposure. Total DNA damage after radiation exposure was estimated by comparing percent double-strand breaks (DSBs) in genomic DNA. It was found that all three morphotypes exhibited different radiation tolerances which were also dependent on the radiation dose given. Monococcal forms were found to be most radio-tolerant at most of the tested radiation doses. Results showed that these nutrient-starved-condition induced morphotypes show lesser DNA DSBs upon irradiation, hence show higher radio-tolerance.
- Subjects
DEINOCOCCUS radiodurans; NUTRITION; DNA damage; GAMMA rays; GENOMES
- Publication
Current Microbiology, 2014, Vol 68, Issue 2, p247
- ISSN
0343-8651
- Publication type
Article
- DOI
10.1007/s00284-013-0472-9