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- Title
Adherence of Shigella dysenteriae 1 to Human Colonic Mucin.
- Authors
Sudha, Purushothaman Sai; Devaraj, Halagowder; Devaraj, Niranjali
- Abstract
The pathogenic potential of Shigella is correlated with the ability of the organism to invade and multiply within the cells of colonic epithelium. Although invasion is the ultimate event, a preceding step is adherence. Shigella dysenteriae 1 preferentially adhered to colonic mucin and not to small intestinal mucin. The pathogen showed a very strong adherence pattern to human colonic mucin when compared with guinea pig and rat mucin. The adherence pattern of S. dysenteriae 1 was not altered on preincubation with monosaccharides present in mucins, suggesting that the receptor for the pathogen is not a simple sugar. Binding of S. dysenteriae 1 to human colonic mucin was not by weak hydrophobic forces. The bacterium also adhered to glycolipids, emphasizing the role of glycoconjugates as receptors for S. dysenteriae 1.
- Subjects
SHIGELLA; ENTEROBACTERIACEAE; EPITHELIUM; TISSUES; MUCINS; GLYCOLIPIDS; GLYCOCONJUGATES
- Publication
Current Microbiology, 2001, Vol 42, Issue 6, p381
- ISSN
0343-8651
- Publication type
Article
- DOI
10.1007/s002840010234