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- Title
Transcriptomic characteristics according to tumor size and SUV<sub>max</sub> in papillary thyroid cancer patients.
- Authors
Ju, Sang-Hyeon; Lee, Seong Eun; Yi, Shinae; Choi, Na Rae; Kim, Kun Ho; Kim, Seong Min; Koh, June-Young; Kim, Seon-Kyu; Kim, Seon-Young; Heo, Jun Young; Park, Junyoung O.; Park, Seongyeol; Koo, Bon Seok; Kang, Yea Eun
- Abstract
The SUVmax is a measure of FDG uptake and is related with tumor aggressiveness in thyroid cancer, however, its association with molecular pathways is unclear. Here, we investigated the relationship between SUVmax and gene expression profiles in 80 papillary thyroid cancer (PTC) patients. We conducted an analysis of DEGs and enriched pathways in relation to SUVmax and tumor size. SUVmax showed a positive correlation with tumor size and correlated with glucose metabolic process. The genes that indicate thyroid differentiation, such as SLC5A5 and TPO, were negatively correlated with SUVmax. Unsupervised analysis revealed that SUVmax positively correlated with DNA replication(r = 0.29, p = 0.009), pyrimidine metabolism(r = 0.50, p < 0.0001) and purine metabolism (r = 0.42, p = 0.0001). Based on subgroups analysis, we identified that PSG5, TFF3, SOX2, SL5A5, SLC5A7, HOXD10, FER1L6, and IFNA1 genes were found to be significantly associated with tumor aggressiveness. Both high SUVmax PTMC and macro-PTC are enriched in pathways of DNA replication and cell cycle, however, gene sets for purine metabolic pathways are enriched only in high SUVmax macro-PTC but not in high SUVmax PTMC. Our findings demonstrate the molecular characteristics of high SUVmax tumor and metabolism involved in tumor growth in differentiated thyroid cancer.
- Subjects
THYROID cancer; THYROGLOBULIN; CANCER patients; DNA replication; GENE expression profiling; TRANSCRIPTOMES
- Publication
Scientific Reports, 2024, Vol 14, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-024-61839-0