We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Intravitreal Ranibizumab for neovascular Age-related macular degeneration in clinical practice: five-year treatment outcomes.
- Authors
Zhu, Meidong; Chew, Jamie; Broadhead, Geoffrey; Luo, Kehui; Joachim, Nichole; Hong, Thomas; Syed, Adil; Chang, Andrew
- Abstract
Background: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents are the established standard of care for neovascular age-related macular degeneration (nAMD). However, data on long-term outcomes of this therapy are limited. The purpose of this study was to assess the visual and anatomical outcomes and safety profile of intravitreal ranibizumab in treating nAMD over a period of five years. Methods: 208 patients (208 eyes) were included in this retrospective case series study. Intervention was an 'as-needed' treatment model. Visual acuity (VA), central macular thickness (CMT), ophthalmic examination, and adverse events (AEs) were assessed in each visit. Snellen VA was converted to Early Treatment Diabetic Retinopathy Study letters for analysis. Results: The average VA improved by 1.9 letters after one year ( p = 0.017), and decreased by 2.4 letters over five years of treatment ( p = 0.043). At the end of year five, 11.1 % of patients (23/208) had improved VA by more than 15 letters and 68.8 % (143/208) had VA improvement or loss less than or equal to 15 letters, while 20.2 % of patients (42/208) had a loss of more than 15 letters. Patients with VA of less than 35 letters at baseline showed significant VA improvement after five years of treatment. There was a positive relationship between injection numbers and VA improvement over the five-year period, after adjusting for age and baseline VA ( p < 0.0005). Mean CMT decreased by 28.3 μm ( p < 0.0005) over five years. Ocular AEs, serious adverse events (SAEs), and systemic SAEs occurred in 4.6 %, 0.48 %, and 2 % of patients, respectively, during the follow-up period. Conclusions: The use of intravitreal ranibizumab in an as-needed treatment regimen over a five-year period was effective in maintaining vision in patients with nAMD and in reducing macular thickness, with a relatively low rate of adverse and serious adverse events.
- Subjects
RANIBIZUMAB; VASCULAR endothelial growth factor antagonists; RETINAL degeneration; TREATMENT effectiveness; OCULAR injuries; OPHTHALMOLOGY; EYE diseases; PRACTICE of optometry
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2015, Vol 253, Issue 8, p1217
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-014-2799-8