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- Title
Prevalence and Outcomes of Head and Neck versus Non-Head and Neck Second Primary Malignancies in Head and Neck Squamous Cell Carcinoma: An Analysis of the Surveillance, Epidemiology, and End Results Database.
- Authors
Birkeland, andrew C.; Rosko, andrew J.; Chinn, Steven B.; Prince, Mark E.; Sun, Gordon H.; Spector, Matthew E.
- Abstract
<bold>Background/aims: </bold>Patients with head and neck squamous cell carcinoma (HNSCC) are at risk for second primary malignancies (SPMs). The prevalence, distribution, and patient survival in head and neck versus non-head and neck SPMs are not fully elucidated. The objective of this study was to quantify the rate of SPMs in patients with HNSCC.<bold>Methods: </bold>This is a population-based cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Prevalence and location of SPMs, and survival data were analyzed.<bold>Results: </bold>There were 58,363 HNSCC patients, and the prevalence of HNSCC and non-HNSCC SPMs was 3.0% (1,746) and 8.8% (5,109), respectively. Overall survival (OS) was higher in patients with HNSCC SPMs compared to non-HNSCC SPMs (p < 0.001), with no difference in disease-specific survival. Patients with SPMs in the lung and esophagus had a worse OS (p < 0.001), and patients with SPMs in the prostate and breast had a better OS (p < 0.001).<bold>Conclusion: </bold>In HNSCC patients who develop SPMs, nearly 75% are non-HNSCC SPMs. Patients with non-HNSCC SPMs have a lower OS. Future clinical practice guidelines should take the risks and locations of SPM development into consideration for screening.
- Subjects
UNITED States; HEAD &; neck cancer; SQUAMOUS cell carcinoma; SECONDARY primary cancer; CANCER patients; EPIDEMIOLOGY; REPORTING of diseases; HEAD tumors; LONGITUDINAL method; NECK tumors; RESEARCH funding; RISK assessment; SURVIVAL; TUMOR classification; DISEASE prevalence; RETROSPECTIVE studies; DIAGNOSIS
- Publication
ORL, 2016, Vol 78, Issue 2, p61
- ISSN
0301-1569
- Publication type
journal article
- DOI
10.1159/000443768